Causative Role of Coronary Microvessels for the Development and Progression of Chronic Myocardial Lesions in Spontaneously Hypertensive Rats (SHR)

Overview

Journal Basic Res Cardiol

Specialty Cardiology & Vascular Diseases

Date 1992 Sep 1

PMID 1463432

Citations 1

Authors

H J Herrmann

P Muhlig

Affiliations

Soon will be listed here.

Abstract

The pathomechanisms responsible for the development and progression of myocardial alterations in hypertensive heart disease are largely unknown. Using newly developed preparation and measuring procedures in 78 SHR and 82 controls aged 3-78 weeks, topological relations were detected between focal morphological appearances of chronic myocardial ischemia (fml.) and pathological microvessel (mv.) reactions characterized by morphometric signs of chronic contractions. The smallest ramifications are of particular pathogenic importance. A generalized peak of pathological mv. reactions between the 16th and 24th weeks is responsible for the development of first fml. The further progression of the area density of fml. from 1.26 +/- 0.85% (24th week) to 31.82 +/- 8.60% (78th week) is attributable to the further increase in pathological mv. reactions caused by organ-specific influences. The histological and morphometric findings suggest that the pathological mv. reactions are aggravated by their own effects at the local level.

Citing Articles

Effect of noise stress and ethanol intake on hearts of spontaneously hypertensive rats.

Herrmann H, Rohde H, Schulze W, Eichhorn C, Luft F Basic Res Cardiol. 1994; 89(6):510-23.

PMID: 7702540 DOI: 10.1007/BF00794951.

References

Yurenev A, DeQuattro V, Devereux R . Hypertensive heart disease: relationship of silent ischemia to coronary artery disease and left ventricular hypertrophy. Am Heart J. 1990; 120(4):928-33. DOI: 10.1016/0002-8703(90)90212-g. View

Duling B, Pittman R . Oxygen tension: dependent or independent variable in local control of blood flow?. Fed Proc. 1975; 34(11):2012-9. View

RAKUSAN K, Wicker P, Abdul-Samad M, Healy B, Turek Z . Failure of swimming exercise to improve capillarization in cardiac hypertrophy of renal hypertensive rats. Circ Res. 1987; 61(5):641-7. DOI: 10.1161/01.res.61.5.641. View

James T . Morphologic characteristics and functional significance of focal fibromuscular dysplasia of small coronary arteries. Am J Cardiol. 1990; 65(14):12G-22G. DOI: 10.1016/0002-9149(90)90954-y. View

ZWEIFACH B . Microcirculation. Annu Rev Physiol. 1973; 35:117-50. DOI: 10.1146/annurev.ph.35.030173.001001. View

Faber J . In situ analysis of alpha-adrenoceptors on arteriolar and venular smooth muscle in rat skeletal muscle microcirculation. Circ Res. 1988; 62(1):37-50. DOI: 10.1161/01.res.62.1.37. View

Gaasch W, Zile M, Hoshino P, Apstein C, Blaustein A . Stress-shortening relations and myocardial blood flow in compensated and failing canine hearts with pressure-overload hypertrophy. Circulation. 1989; 79(4):872-83. DOI: 10.1161/01.cir.79.4.872. View

Hittinger L, Shannon R, Bishop S, Gelpi R, Vatner S . Subendomyocardial exhaustion of blood flow reserve and increased fibrosis in conscious dogs with heart failure. Circ Res. 1989; 65(4):971-80. DOI: 10.1161/01.res.65.4.971. View

Grande P, Borgstrom P, Mellander S . On the nature of basal vascular tone in cat skeletal muscle and its dependence on transmural pressure stimuli. Acta Physiol Scand. 1979; 107(4):365-76. DOI: 10.1111/j.1748-1716.1979.tb06487.x. View

10.

Herrmann H, Muhlig P, Blodner R, Kuhne C . Histomorphometry of focal myocardial lesions by means of the automatic image analysis. Exp Toxicol Pathol. 1992; 44(2):108-10. DOI: 10.1016/S0940-2993(11)80198-3. View

11.

Houghton J, Frank M, CARR A, von Dohlen T, Prisant L . Relations among impaired coronary flow reserve, left ventricular hypertrophy and thallium perfusion defects in hypertensive patients without obstructive coronary artery disease. J Am Coll Cardiol. 1990; 15(1):43-51. DOI: 10.1016/0735-1097(90)90173-m. View

12.

Herrmann H, Muhlig P, Kuhne C, Blodner R . Progress in the histomorphometry of the microcirculatory system. Gegenbaurs Morphol Jahrb. 1989; 135(1):109-14. View

13.

Factor S, Minase T, Cho S, Fein F, Capasso J, SONNENBLICK E . Coronary microvascular abnormalities in the hypertensive-diabetic rat. A primary cause of cardiomyopathy?. Am J Pathol. 1984; 116(1):9-20. PMC: 1900375. View

14.

Herrmann H, Muhlig P, Kuhne C, Lauter J . Automated image analysis for measurements of morphological reactions of blood vessels of the microvascular system. Exp Pathol (Jena). 1979; 17(4):215-27. DOI: 10.1016/s0014-4908(79)80015-0. View

15.

Donohue S, Stitzel R, Head R . Time course of changes in the norepinephrine content of tissues from spontaneously hypertensive and Wistar Kyoto rats. J Pharmacol Exp Ther. 1988; 245(1):24-31. View

16.

Woodman O . The role of alpha 1- and alpha 2-adrenoceptors in the coronary vasoconstrictor responses to neuronally released and exogenous noradrenaline in the dog. Naunyn Schmiedebergs Arch Pharmacol. 1987; 336(2):161-8. DOI: 10.1007/BF00165800. View

17.

Amann K, Greber D, Gharehbaghi H, Wiest G, Lange B, Ganten U . Effects of nifedipine and moxonidine on cardiac structure in spontaneously hypertensive rats. Stereological studies on myocytes, capillaries, arteries, and cardiac interstitium. Am J Hypertens. 1992; 5(2):76-83. DOI: 10.1093/ajh/5.2.76. View

18.

Hecht A . [Enzymatic histochemical reactions in the rat myocardium following temporary ischemia]. Exp Pathol (Jena). 1971; 5(1):28-36. View

19.

Warnock P, Docherty J . Further investigation of the sites of vascular alpha 1 and alpha 2 adrenoceptors in the anaesthetised spontaneously hypertensive rat. J Cardiovasc Pharmacol. 1986; 8(1):67-70. DOI: 10.1097/00005344-198601000-00011. View

20.

Friberg P, NORDLANDER M . Influence of left ventricular and coronary vascular hypertrophy on cardiac performance. J Hypertens. 1990; 8(10):879-89. DOI: 10.1097/00004872-199010000-00001. View