Reproductive Toxicity and Toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin. 3. Effects of Single Doses on the Testis of Male Rats

Overview

Journal Arch Toxicol

Specialty Toxicology

Date 1992 Jan 1

PMID 1463392

Citations 8

Authors

I Chahoud

J Hartmann

G M Rune

D Neubert

Affiliations

Soon will be listed here.

Abstract

The effects of a single dose of TCDD on the testis were studied in rats. The animals were treated (subcutaneously) once with TCDD doses of 0, 0.5, 1.0, 3.0, 5.0 micrograms/kg body weight. Doses of 3.0 or 5.0 micrograms TCDD/kg reduced the number of spermatids/testis significantly (60% of the controls). Electron microscopic inspection revealed that both doses led to a dissolution on the germinal epithelium. Altered germ cells at all developmental stages occurred in all testes evaluated. Doses of 0.5 or 1.0 micrograms TCDD/kg did not induce any effects in the testis; therefore, under these experimental conditions of single exposure to rats the dose of 1.0 micrograms TCDD/kg can be considered as NOAEL.

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