Mitochondrial Regulation of Intracellular Ca2+ Signaling: More Than Just Simple Ca2+ Buffers

Overview

Journal News Physiol Sci

Specialty Physiology

Date 2003 Nov 14

PMID 14614159

Citations 30

Authors

Anant B Parekh

Affiliations

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Abstract

Mitochondrial Ca(2+) uptake shapes the profile of intracellular Ca(2+) signals, both spatially and temporally. In addition, such uptake controls the gating of Ca(2+) release and store-operated Ca(2+) entry channels, partitions cells into subcellular Ca(2+) hotspots, and can result in the release of diffusible signals into the cytosol that subsequently regulate protein function.

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