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Equilibrium Free Energies from Nonequilibrium Measurements Using Maximum-likelihood Methods

Overview
Journal Phys Rev Lett
Specialty Biophysics
Date 2003 Nov 13
PMID 14611511
Citations 127
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Abstract

We present a maximum likelihood argument for the Bennett acceptance ratio method, and derive a simple formula for the variance of free energy estimates generated using this method. This derivation of the acceptance ratio method, using a form of logistic regression, a common statistical technique, allows us to shed additional light on the underlying physical and statistical properties of the method. For example, we demonstrate that the acceptance ratio method yields the lowest variance for any estimator of the free energy which is unbiased in the limit of large numbers of measurements.

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