AII Amacrine Neurons of the Rat Retina Show Diurnal and Circadian Rhythms of Parvalbumin Immunoreactivity

Overview

Journal Cell Tissue Res

Specialties Anatomy & Histology
Cell Biology

Date 2003 Nov 12

PMID 14610664

Citations 13

Authors

Robert Gabriel

Joseph LeSauter

Tamas Banvolgyi

Gyorgy Petrovics

Rae Silver

Paul Witkovsky

Affiliations

Soon will be listed here.

Abstract

We investigated parvalbumin immunoreactivity (PA-IR) in the retinas of rats maintained on a 12:12 h light:dark cycle, or after being placed in constant darkness for 24-72 h. Retinas were harvested at zeitgeber and circadian times 02:00, 06:00, 10:00, 14:00, 18:00 and 22:00 h. PA-IR was found primarily in retinal amacrine cells of the AII subtype. In a light/dark cycle, PA-IR showed a clear rhythm, with a low near zeitgeber time (ZT) 10:00 h and a peak near ZT 18:00 h. The ratio of immunofluorescence intensities at these timepoints was >15-fold. When animals were kept in complete darkness for 1-3 days, the rhythm of PA-IR was still preserved, but was progressively reduced in amplitude. The rhythm of PA-IR inferred from immunohistochemical data was confirmed by Western blots. We conclude that PA-IR in the rat retina shows an underlying circadian rhythm that is enhanced by cyclic light. The regulation may involve translocation of the protein between cell compartments and/or new protein synthesis.

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