Identification of Sentinel Lymph Nodes in Colon Cancer Depends on the Amount of Dye Injected Relative to Tumor Size

Overview

Journal World J Surg

Publisher Wiley

Specialty General Surgery

Date 2003 Nov 5

PMID 14595521

Citations 19

Authors

Carsten T Viehl

Christian T Hamel

Walter R Marti

Ulrich Guller

Lukas Eisner

Uz Stammberger

Luigi Terracciano

Hans P Spichtin

Felix Harder

Markus Zuber

Affiliations

Soon will be listed here.

Abstract

Recent studies have shown that the sentinel lymph node (SLN) procedure might improve staging in colon cancer. However, low SLN identification and high false negative rates have also been reported. In a two-institution study, the SLN procedure with isosulfan blue 1% was performed according to a standardized protocol in 31 patients with open resections for colon cancer. Data were collected prospectively. The database was analyzed retrospectively to determine factors contributing to a low identification rate. The SLN identification rate was 87% and the false negative rate was 50%. Successful SLN identification was significantly associated with application of higher volumes of dye relative to the tumor diameter ( p = 0.04) and more frequent tumor localization in the sigmoid colon ( p = 0.04) as compared to missing SLN identification. The tumor diameter was not significantly different in the two groups. Sentinel lymph node identification in colon cancer depends on the amount of dye injected relative to the tumor size. Application of only 1 ml of dye-the amount generally recommended in the literature-is not sufficient in large tumors.

Citing Articles

Lymphatic Mapping in Colon Cancer Depending on Injection Time and Tracing Agent: A Systematic Review and Meta-Analysis of Prospective Designed Studies.

Lucas K, Melling N, Giannou A, Reeh M, Mann O, Hackert T Cancers (Basel). 2023; 15(12).

PMID: 37370806 PMC: 10296374. DOI: 10.3390/cancers15123196.

The Simultaneous Presence of Isolated Tumour Cells and Bone Marrow Micrometastases in Stage I and II Colon Cancer-Challenging the Theory of a Chronological Pathway of Tumour Cell Dissemination.

Ramser M, Warschkow R, Viehl C, Kettelhack C, Zettl A, Lobbes L World J Surg. 2021; 46(3):680-689.

PMID: 34958413 PMC: 8803740. DOI: 10.1007/s00268-021-06399-4.

Comparative Analysis of Tumor Cell Dissemination to the Sentinel Lymph Nodes and to the Bone Marrow in Patients With Nonmetastasized Colon Cancer: A Prospective Multicenter Study.

Weixler B, Viehl C, Warschkow R, Guller U, Ramser M, Sauter G JAMA Surg. 2017; 152(10):912-920.

PMID: 28593306 PMC: 5710278. DOI: 10.1001/jamasurg.2017.1514.

Sentinel Lymph Node Mapping with Isosulfan Blue or Indocyanine Green in Colon Cancer Shows Comparable Results and Identifies Patients with Decreased Survival: A Prospective Single-Center Trial.

Weixler B, Rickenbacher A, Raptis D, Viehl C, Guller U, Rueff J World J Surg. 2017; 41(9):2378-2386.

PMID: 28508233 DOI: 10.1007/s00268-017-4051-2.

Intranodal Mapping Using Carbon Dye Results in More Accurate Lymph Node Staging in Colon Cancer Patients.

Weixler B, Warschkow R, Zettl A, Riehle H, Guller U, Viehl C World J Surg. 2015; 39(10):2583-9.

PMID: 26154574 DOI: 10.1007/s00268-015-3130-5.

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