Maintenance of Heterochromatin by RNA Interference of Tandem Repeats

Overview

Journal Nat Genet

Specialty Genetics

Date 2003 Nov 1

PMID 14593407

Citations 72

Authors

Robert A Martienssen

Affiliations

Soon will be listed here.

Abstract

Tandem repeats are prone to epigenetic silencing regulated by RNA interference. This may be because siRNAs from tandem array transcripts are regenerated by RNA-dependent RNA polymerase (RdRP) and Dicer, but siRNAs from single-copy sequences are exhausted by sequential use of downstream primers by RdRP. This could account for the formation of heterochromatin from tandem repeats.

Citing Articles

Ectopic enhancer-enhancer interactions as causal forces driving RNA-directed DNA methylation in gene regulatory regions.

Yang Y, Liu J, Singer S, Yan G, Bennet D, Liu Y Plant Biotechnol J. 2024; 22(11):3121-3134.

PMID: 39021281 PMC: 11500991. DOI: 10.1111/pbi.14435.

Paramutation at the maize pl1 locus is associated with RdDM activity at distal tandem repeats.

Deans N, Talbot J, Li M, Saez-Gonzalez C, Hovel I, Heavens D PLoS Genet. 2024; 20(5):e1011296.

PMID: 38814980 PMC: 11166354. DOI: 10.1371/journal.pgen.1011296.

Cytogenetic Analysis of Satellitome of Madagascar Leaf-Tailed Geckos.

Yurchenko A, Psenicka T, Mora P, Ortega J, Sanchez Baca A, Rovatsos M Genes (Basel). 2024; 15(4).

PMID: 38674364 PMC: 11049218. DOI: 10.3390/genes15040429.

Arms race between anti-silencing and RdDM in noncoding regions of transposable elements.

Sasaki T, Kato K, Hosaka A, Fu Y, Toyoda A, Fujiyama A EMBO Rep. 2023; 24(8):e56678.

PMID: 37272687 PMC: 10398659. DOI: 10.15252/embr.202256678.

DDM1-Mediated TE Silencing in Plants.

Akinmusola R, Wilkins C, Doughty J Plants (Basel). 2023; 12(3).

PMID: 36771522 PMC: 9919755. DOI: 10.3390/plants12030437.