Herpes Simplex Virus UL14 Protein Blocks Apoptosis

Overview

Journal Microbiol Immunol

Specialties Allergy & Immunology
Microbiology

Date 2003 Oct 31

PMID 14584616

Citations 10

Authors

Yohei Yamauchi

Tohru Daikoku

Fumi Goshima

Yukihiro Nishiyama

Affiliations

Soon will be listed here.

Abstract

We report that an HSV-2 UL14 protein expressing cell line (14/HEp-2) was more resistant to apoptosis induced by osmotic shock and certain drugs than its parental cell line. Furthermore, HSV-1 UL14 protein deletion virus (UL14D) showed weaker inhibition of apoptosis compared to the rescued virus UL14R. The protein's anti-apoptotic function may derive from its heat shock protein-like properties.

Citing Articles

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Multiple functions of the herpesvirus UL14 gene product in viral infection.

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The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.

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