Synergism Between the Brushite and Hydroxyapatite Urinary Crystallization Inhibitors

Overview

Journal Int Urol Nephrol

Publisher Springer

Specialty Nephrology

Date 2003 Oct 28

PMID 14577482

Citations 1

Authors

Antonia Costa-Bauza

Catalina Barcelo

Juan Perello

Felix Grases

Affiliations

Soon will be listed here.

Abstract

The aim of this paper is to study possible synergic effects between crystallization-inhibitor molecules of low molecular weight on the hydroxyapatite and brushite crystal nucleation. Kinetic-turbidimetric measurements were performed to follow the nucleation process in synthetic urine at 37 degrees C. Only pyrophosphate + phytate mixture manifested synergic effects on the brushite nucleation, whereas the mixture pyrophosphate + citrate exhibited synergic effects only on the hydroxyapatite nucleation. It seems clear that synergic effects between the crystallization inhibitory capacity of some substances in urine can take place and as a consequence, the high crystallization inhibitory capacity of healthy urine could be assigned not only to the individual inhibitory capacity of each product but also to the synergic effects between different products.

Citing Articles

Targeted microbubbles: a novel application for the treatment of kidney stones.

Ramaswamy K, Marx V, Laser D, Kenny T, Chi T, Bailey M BJU Int. 2014; 116(1):9-16.

PMID: 25402588 PMC: 4433869. DOI: 10.1111/bju.12996.

References

See W, Williams R . Urothelial injury and clotting cascade activation: common denominators in particulate adherence to urothelial surfaces. J Urol. 1992; 147(3):541-8. DOI: 10.1016/s0022-5347(17)37302-0. View

Grases F, Costa-Bauza A . Study of the early stages of renal stone formation: experimental model using urothelium of pig urinary bladder. Urol Res. 1996; 24(5):305-11. DOI: 10.1007/BF00304781. View

Pak C . Citrate and renal calculi. Miner Electrolyte Metab. 1987; 13(4):257-66. View

Hess B . The role of Tamm-Horsfall glycoprotein and Nephrocalcin in calcium oxalate monohydrate crystallization processes. Scanning Microsc. 1991; 5(3):689-95; discussion 696. View

Hoyer J . Uropontin in urinary calcium stone formation. Miner Electrolyte Metab. 1994; 20(6):385-92. View

Nakagawa Y, Abram V, Coe F . Isolation of calcium oxalate crystal growth inhibitor from rat kidney and urine. Am J Physiol. 1984; 247(5 Pt 2):F765-72. DOI: 10.1152/ajprenal.1984.247.5.F765. View

Grases F, Costa-Bauza A, Konigsberger E, Konigsberger L . Kinetic versus thermodynamic factors in calcium renal lithiasis. Int Urol Nephrol. 2000; 32(1):19-27. DOI: 10.1023/a:1007105328211. View

Hess B . Tamm-Horsfall glycoprotein--inhibitor or promoter of calcium oxalate monohydrate crystallization processes?. Urol Res. 1992; 20(1):83-6. DOI: 10.1007/BF00294343. View

Grases F, Sohnel O, Vilacampa A, March J . Phosphates precipitating from artificial urine and fine structure of phosphate renal calculi. Clin Chim Acta. 1996; 244(1):45-67. DOI: 10.1016/0009-8981(95)06179-7. View

10.

Worcester E, Nakagawa Y, Coe F . Glycoprotein calcium oxalate crystal growth inhibitor in urine. Miner Electrolyte Metab. 1987; 13(4):267-72. View

11.

Grases F, Masarova L, Sohnel O, Costa-Bauza A . Agglomeration of calcium oxalate monohydrate in synthetic urine. Br J Urol. 1992; 70(3):240-6. DOI: 10.1111/j.1464-410x.1992.tb15724.x. View

12.

Shum D, Gohel M . Separate effects of urinary chondroitin sulphate and heparan sulphate on the crystallization of urinary calcium oxalate: differences between stone formers and normal control subjects. Clin Sci (Lond). 1993; 85(1):33-9. DOI: 10.1042/cs0850033. View

13.

Ryall R, Harnett R, Marshall V . The effect of urine, pyrophosphate, citrate, magnesium and glycosaminoglycans on the growth and aggregation of calcium oxalate crystals in vitro. Clin Chim Acta. 1981; 112(3):349-56. DOI: 10.1016/0009-8981(81)90458-7. View

14.

Fleisch H, BISAZ S . Isolation from urine of pyrophosphate, a calcification inhibitor. Am J Physiol. 1962; 203:671-5. DOI: 10.1152/ajplegacy.1962.203.4.671. View

15.

Scurr D, Robertson W . Modifiers of calcium oxalate crystallization found in urine. III. Studies on the role of Tamm-Horsfall mucoprotein and of ionic strength. J Urol. 1986; 136(2):505-7. DOI: 10.1016/s0022-5347(17)44931-7. View

16.

Meyer J, Smith L . Growth of calcium oxalate crystals. II. Inhibition by natural urinary crystal growth inhibitors. Invest Urol. 1975; 13(1):36-9. View

17.

Grases F, Costa-Bauza A, March J . Study of the effects of different substances on the early stages of papillary stone formation. Nephron. 1996; 73(4):561-8. DOI: 10.1159/000189141. View