Ras GTPases: Integrins' Friends or Foes?

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2003 Oct 23

PMID 14570053

Citations 85

Authors

Kayoko Kinbara

Lawrence E Goldfinger

Malene Hansen

Fan-Li Chou

Mark H Ginsberg

Affiliations

Soon will be listed here.

Abstract

Integrins are cell-surface receptors that mediate and coordinate cellular responses to the extracellular matrix (ECM). Cellular signalling pathways can regulate cell adhesion by altering the affinity and avidity of integrins for ECM. The Ras family of small G proteins, which includes H-ras, R-ras and Rap, are important elements in cellular signalling pathways that control integrin function.

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