Stress and the Immune System

Stressors can positively or adversely affect immune and inflammatory responses. However, the current understanding of these effects at the cellular and molecular levels is not sufficient to allow prediction of the effects of a particular stressor on a particular immune or inflammatory function. Three complementary conceptual frameworks are presented that may prove useful in developing such an understanding. In addition, specific examples of the action of particular stress mediators on particular immune or inflammatory end points are discussed, and the relationship of these observations to the conceptual frameworks is indicated. Several of the effects discussed are relevant clinically, and the prospects for pharmacological intervention to prevent adverse effects of stressors on the immune system are discussed. Finally, some of the factors that can (sometimes unexpectedly) influence the outcome of stress-immunology studies and some of the pitfalls that continue to make this area of research controversial in some circles are discussed.