The Novel Gluconeogenesis Inhibitors FR225659 and Related Compounds That Originate from Helicomyces Sp. No. 19353. I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties

FR225659 and four related compounds are novel gluconeogenesis inhibitors that consist of a novel acyl-group and three abnormal amino acids. They were isolated from the culture broth of Helicomyces sp. No. 19353 and can be purified by absorptive resin and reverse-phase column chromatography. They are potent inhibitors of gluconeogenesis in primary cultured rat hepatocytes and thus may be useful as anti-diabetic agents.