Hypertension and Dementia

Overview

Journal Curr Cardiol Rep

Publisher Current Science

Specialty Cardiology & Vascular Diseases

Date 2003 Oct 16

PMID 14558983

Citations 11

Authors

Olivier Hanon

Marie Laure Seux

Hermine Lenoir

Anne Sophie Rigaud

Francoise Forette

Affiliations

Soon will be listed here.

Abstract

Hypertension is one of the principal risk factors for cerebrovascular diseases. Several epidemiologic studies have also indicated a positive correlation between cognitive decline or dementia and blood pressure level. Indeed, the results of most longitudinal studies show that cognitive functioning is often inversely proportional to blood pressure values measured 15 or 20 years previously. Cerebral infarcts, lacunae, and white matter changes are implicated in the pathogenesis of vascular dementia, but may also favor the development of Alzheimer's disease. Microcirculation disorders and endothelial dysfunctions are also advanced to explain the deterioration in cognitive functions in hypertensive subjects. Data from recent therapeutic trials open the way to the prevention of dementia (vascular or Alzheimer's type) by antihypertensive treatments and must be confirmed by other studies.

Citing Articles

Adherence to the Mediterranean Diet, Sodium and Potassium Intake in People at a High Risk of Dementia.

Rodrigues J, Costa M, Sousa D, Costa A, Lunet N, Cruz V Nutrients. 2024; 16(10).

PMID: 38794657 PMC: 11124415. DOI: 10.3390/nu16101419.

Pressure control and treatment interact in the deterioration of incidental visuospatial memory in hypertensive patients.

Lopez-Vazquez M, Varela-Montes J, Serrano-Corral M, Junco-Munoz M, Olvera-Cortes M Arch Cardiol Mex. 2024; 94(1):25-32.

PMID: 38507327 PMC: 11160517. DOI: 10.24875/ACM.22000290.

Chronic Neuroinflammation and Cognitive Decline in Patients with Cardiac Disease: Evidence, Relevance, and Therapeutic Implications.

Traub J, Frey A, Stork S Life (Basel). 2023; 13(2).

PMID: 36836686 PMC: 9962280. DOI: 10.3390/life13020329.

Associations of centrally acting ACE inhibitors with cognitive decline and survival in Alzheimer's disease.

Fazal K, Perera G, Khondoker M, Howard R, Stewart R BJPsych Open. 2017; 3(4):158-164.

PMID: 28713585 PMC: 5495996. DOI: 10.1192/bjpo.bp.116.004184.

Acupuncture with reinforcing and reducing twirling manipulation inhibits hippocampal neuronal apoptosis in spontaneously hypertensive rats.

Lu J, Guo Y, Guo C, Shi X, Du N, Zhao R Neural Regen Res. 2017; 12(5):770-778.

PMID: 28616034 PMC: 5461615. DOI: 10.4103/1673-5374.206648.

References

Strandgaard S, Paulson O . Cerebrovascular consequences of hypertension. Lancet. 1994; 344(8921):519-21. DOI: 10.1016/s0140-6736(94)91903-8. View

Henon H, Pasquier F, Durieu I, Godefroy O, Lucas C, Lebert F . Preexisting dementia in stroke patients. Baseline frequency, associated factors, and outcome. Stroke. 1997; 28(12):2429-36. DOI: 10.1161/01.str.28.12.2429. View

Forette F, Seux M, Staessen J, Thijs L, Babarskiene M, Babeanu S . The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med. 2002; 162(18):2046-52. DOI: 10.1001/archinte.162.18.2046. View

Launer L, Ross G, Petrovitch H, Masaki K, Foley D, White L . Midlife blood pressure and dementia: the Honolulu-Asia aging study. Neurobiol Aging. 2000; 21(1):49-55. DOI: 10.1016/s0197-4580(00)00096-8. View

Hardy J, Mann D, Wester P, Winblad B . An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease. Neurobiol Aging. 1986; 7(6):489-502. DOI: 10.1016/0197-4580(86)90086-2. View

Di Bari M, Pahor M, Franse L, Shorr R, Wan J, Ferrucci L . Dementia and disability outcomes in large hypertension trials: lessons learned from the systolic hypertension in the elderly program (SHEP) trial. Am J Epidemiol. 2001; 153(1):72-8. DOI: 10.1093/aje/153.1.72. View

Pohjasvaara T, Erkinjuntti T, Ylikoski R, Hietanen M, Vataja R, Kaste M . Clinical determinants of poststroke dementia. Stroke. 1998; 29(1):75-81. DOI: 10.1161/01.str.29.1.75. View

Skoog I, Lernfelt B, Landahl S, Palmertz B, Andreasson L, Nilsson L . 15-year longitudinal study of blood pressure and dementia. Lancet. 1996; 347(9009):1141-5. DOI: 10.1016/s0140-6736(96)90608-x. View

. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. JAMA. 1991; 265(24):3255-64. View

10.

Longstreth Jr W, Manolio T, Arnold A, Burke G, Bryan N, Jungreis C . Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke. 1996; 27(8):1274-82. DOI: 10.1161/01.str.27.8.1274. View

11.

Yoshitake T, Kiyohara Y, Kato I, Ohmura T, Iwamoto H, Nakayama K . Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: the Hisayama Study. Neurology. 1995; 45(6):1161-8. DOI: 10.1212/wnl.45.6.1161. View

12.

Lithell H, Hansson L, Skoog I, Elmfeldt D, Hofman A, Olofsson B . The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial. J Hypertens. 2003; 21(5):875-86. DOI: 10.1097/00004872-200305000-00011. View

13.

Hamet P, Richard L, Dam T, Teiger E, Orlov S, Gaboury L . Apoptosis in target organs of hypertension. Hypertension. 1995; 26(4):642-8. DOI: 10.1161/01.hyp.26.4.642. View

14.

Elias M, Wolf P, DAgostino R, Cobb J, White L . Untreated blood pressure level is inversely related to cognitive functioning: the Framingham Study. Am J Epidemiol. 1993; 138(6):353-64. DOI: 10.1093/oxfordjournals.aje.a116868. View

15.

Okumiya K, Matsubayashi K, Wada T, Osaki Y, Doi Y, Ozawa T . J-curve relation between blood pressure and decline in cognitive function in older people living in community, Japan. J Am Geriatr Soc. 1997; 45(8):1032-3. DOI: 10.1111/j.1532-5415.1997.tb02981.x. View

16.

ONeill C, Cowburn R, Bonkale W, Ohm T, Fastbom J, Carmody M . Dysfunctional intracellular calcium homoeostasis: a central cause of neurodegeneration in Alzheimer's disease. Biochem Soc Symp. 2001; (67):177-94. DOI: 10.1042/bss0670177. View

17.

Prince M, Bird A, Blizard R, Mann A . Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council's trial of hypertension in older adults. BMJ. 1996; 312(7034):801-5. PMC: 2350726. DOI: 10.1136/bmj.312.7034.801. View

18.

Vagnucci Jr A, Li W . Alzheimer's disease and angiogenesis. Lancet. 2003; 361(9357):605-8. DOI: 10.1016/S0140-6736(03)12521-4. View

19.

Murray M, Lane K, Gao S, Evans R, Unverzagt F, Hall K . Preservation of cognitive function with antihypertensive medications: a longitudinal analysis of a community-based sample of African Americans. Arch Intern Med. 2002; 162(18):2090-6. DOI: 10.1001/archinte.162.18.2090. View

20.

Arregui A, Perry E, Rossor M, Tomlinson B . Angiotensin converting enzyme in Alzheimer's disease increased activity in caudate nucleus and cortical areas. J Neurochem. 1982; 38(5):1490-2. DOI: 10.1111/j.1471-4159.1982.tb07930.x. View