Anthrax Toxin Induces Hemolysis: an Indirect Effect Through Polymorphonuclear Cells

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2003 Oct 11

PMID 14551883

Citations 4

Authors

Aiguo G Wu

Darya Alibek

Yue Lydia Li

Chris Bradburne

Charles L Bailey

Kenneth Alibek

Affiliations

Soon will be listed here.

Abstract

Anthrax toxin can induce hemolysis in the presence of polymorphonuclear cells (PMNs), an activity primarily mediated by protective antigen, with synergic effects provided by lethal factor and edema factor. Lethal factor and edema factor, individually or in combination, are incapable of lysing red blood cells. The requirement for the presence of PMNs indicates that hemolysis associated with Bacillus anthracis infection is indirect rather than direct, as observed in many other bacterial infections.

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