The Aspartic Proteases

Overview

Journal Scand J Clin Lab Invest Suppl

Specialty Pathology

Date 1992 Jan 1

PMID 1455179

Citations 35

Authors

P B Szecsi

Affiliations

Soon will be listed here.

Abstract

The Aspartic proteases (EC 3.4.23) are a group of proteolytic enzymes that share the same catalytic apparatus. Members of the aspartic protease family can be found in different organisms, ranging from humans to plants and retroviruses. The best known sources of aspartic proteases are the stomach of mammals, yeast and fungi, with porcine pepsin as the proto type. The aim of this review is to summarize some of the characteristics of the aspartic protease family.

Citing Articles

miR-204-5p Protects Nephrin from Enzymatic Degradation in Cultured Mouse Podocytes Treated with Nephrotoxic Serum.

Haddad G, Blaine J Cells. 2025; 14(5).

PMID: 40072092 PMC: 11899291. DOI: 10.3390/cells14050364.

Polymorphism Identification in the Coding Sequences (ORFs) of the Porcine Pregnancy-Associated Glycoprotein 2-like Gene Subfamily in Pigs.

Bieniek-Kobuszewska M, Panasiewicz G Genes (Basel). 2024; 15(9).

PMID: 39336740 PMC: 11431107. DOI: 10.3390/genes15091149.

Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability.

Mulato A, Lansdon E, Aoyama R, Voigt J, Lee M, Liclican A Antimicrob Agents Chemother. 2024; 68(4):e0137323.

PMID: 38380945 PMC: 10989020. DOI: 10.1128/aac.01373-23.

Galectin-3 promotes secretion of proteases that decrease epithelium integrity in human colon cancer cells.

Li S, Pritchard D, Yu L Cell Death Dis. 2023; 14(4):268.

PMID: 37055381 PMC: 10102123. DOI: 10.1038/s41419-023-05789-x.

Obtaining of Recombinant Camel Chymosin and Testing Its Milk-Clotting Activity on Cow's, Goat's, Ewes', Camel's and Mare's Milk.

Akishev Z, Aktayeva S, Kiribayeva A, Abdullayeva A, Baltin K, Mussakhmetov A Biology (Basel). 2022; 11(11).

PMID: 36358248 PMC: 9687658. DOI: 10.3390/biology11111545.