Identification of Growth Hormone Receptor in Localised Neurofibromas of Patients with Neurofibromatosis Type 1

Overview

Journal J Clin Pathol

Specialty Pathology

Date 2003 Sep 30

PMID 14514779

Citations 15

Authors

K S G Cunha

E P Barboza

E C Da Fonseca

Affiliations

Soon will be listed here.

Abstract

Background: The hallmark of neurofibromatosis type 1 (NF1) is the development of multiple neurofibromas. Solitary neurofibroma may occur in an individual who does not have NF1, but multiple neurofibromas tend to develop only in those with NF1. It has been suggested that hormones may influence the neurofibromas of patients with NF1. The evidence that hormones may influence the growth of neurofibromas comes mainly from the observation that localised neurofibromas of patients with NF1 commonly grow during puberty and pregnancy. Because growth hormone (GH) concentrations increase during puberty, it is possible that GH influences the growth of these tumours.

Aims: To investigate the presence of GH receptors (GHRs) in neurofibromas.

Methods: By means of immunohistochemistry, the presence of GHRs was investigated in two groups of patients: 16 patients without NF1 with solitary neurofibromas (group A) and 10 patients with NF1 with localised neurofibromas (group B).

Results: Six of the 16 patients in group A had neurofibromas that were immunopositive for GHR, whereas nine of the 10 patients in group B were immunopositive.

Conclusions: Most patients with NF1 have localised neurofibromas that express GHR. This suggests that GH may play some role in the development of localised neurofibromas in patients with NF1.

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References

Vogel K, Klesse L, Velasco-Miguel S, Meyers K, Rushing E, Parada L . Mouse tumor model for neurofibromatosis type 1. Science. 1999; 286(5447):2176-9. PMC: 3079436. DOI: 10.1126/science.286.5447.2176. View

Billestrup N, Hansen J, Hansen L, Moldrup A, Galsgaard E, Nielsen J . Molecular mechanism of growth hormone signalling. Endocr J. 1998; 45 Suppl:S41-5. DOI: 10.1507/endocrj.45.suppl_s41. View

Ginarte M, Garcia-Caballero T, Fernandez-Redondo V, Beiras A, Toribio J . Expression of growth hormone receptor in benign and malignant cutaneous proliferative entities. J Cutan Pathol. 2000; 27(6):276-82. DOI: 10.1034/j.1600-0560.2000.027006276.x. View

Garcia-Caballero T, Mertani H, Lambert A, Gallego R, Fraga M, Pintos E . Increased expression of growth hormone and prolactin receptors in hepatocellular carcinomas. Endocrine. 2000; 12(3):265-71. DOI: 10.1385/ENDO:12:3:265. View

SHERMAN L, Atit R, Rosenbaum T, Cox A, Ratner N . Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts. J Biol Chem. 2000; 275(39):30740-5. PMC: 3066458. DOI: 10.1074/jbc.M001702200. View

Rui L, Stofega M . SH2-B and SIRP: JAK2 binding proteins that modulate the actions of growth hormone. Recent Prog Horm Res. 2000; 55:293-311. View

Aktan M, Tanakol R, Nalcaci M, Dincol G . Leukemia in a patient treated with growth hormone. Endocr J. 2000; 47(4):471-3. DOI: 10.1507/endocrj.47.471. View

Kaulsay K, Zhu T, Bennett W, Lee K, Lobie P . The effects of autocrine human growth hormone (hGH) on human mammary carcinoma cell behavior are mediated via the hGH receptor. Endocrinology. 2001; 142(2):767-77. DOI: 10.1210/endo.142.2.7936. View

. Evaluation of plasma hormone concentrations in relation to clinical staging in patients with prostatic cancer. British Prostate Study Group. Br J Urol. 1979; 51(5):382-9. DOI: 10.1111/j.1464-410x.1979.tb02891.x. View

10.

Alexander L, Appleton D, Hall R, Ross W, Wilkinson R . Epidemiology of acromegaly in the Newcastle region. Clin Endocrinol (Oxf). 1980; 12(1):71-9. DOI: 10.1111/j.1365-2265.1980.tb03135.x. View

11.

Martuza R, MacLaughlin D, Ojemann R . Specific estradiol binding in schwannomas, meningiomas, and neurofibromas. Neurosurgery. 1981; 9(6):665-71. DOI: 10.1227/00006123-198112000-00009. View

12.

Chaudhuri P, Walker M, Das Gupta T, Beattie C . Steroid receptors in tumors of nerve sheath origin. J Surg Oncol. 1982; 20(4):205-6. DOI: 10.1002/jso.2930200403. View

13.

ANDREWS G . Growth hormone and malignancy. J Clin Pathol. 1983; 36(8):935-7. PMC: 498425. DOI: 10.1136/jcp.36.8.935. View

14.

Ratner R, Hare J . Association of acromegaly and chondrosarcoma. South Med J. 1983; 76(9):1181-2. DOI: 10.1097/00007611-198309000-00034. View

15.

Reed M, Jacoby R . Cutaneous neuroanatomy and neuropathology. Normal nerves, neural-crest derivatives, and benign neural neoplasms in the skin. Am J Dermatopathol. 1983; 5(4):335-62. View

16.

Emerman J, Leahy M, Gout P, Bruchovsky N . Elevated growth hormone levels in sera from breast cancer patients. Horm Metab Res. 1985; 17(8):421-4. DOI: 10.1055/s-2007-1013563. View

17.

Bengtsson B, Eden S, Ernest I, Oden A, Sjogren B . Epidemiology and long-term survival in acromegaly. A study of 166 cases diagnosed between 1955 and 1984. Acta Med Scand. 1988; 223(4):327-35. DOI: 10.1111/j.0954-6820.1988.tb15881.x. View

18.

Lobie P, Breipohl W, Waters M . Growth hormone receptor expression in the rat gastrointestinal tract. Endocrinology. 1990; 126(1):299-306. DOI: 10.1210/endo-126-1-299. View

19.

Cawthon R, Weiss R, Xu G, Viskochil D, Culver M, Stevens J . A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations. Cell. 1990; 62(1):193-201. DOI: 10.1016/0092-8674(90)90253-b. View

20.

Wallace M, Marchuk D, Andersen L, Letcher R, Odeh H, Saulino A . Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. Science. 1990; 249(4965):181-6. DOI: 10.1126/science.2134734. View