Thiersindoles A-C: New Indole Diterpenoids from Penicillium Thiersii

Overview

Journal J Nat Prod

Date 2003 Sep 27

PMID 14510604

Citations 8

Authors

Chen Li

James B Gloer

Donald T Wicklow

Affiliations

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Abstract

Three new 3-substituted indole diterpenoids (thiersindoles A-C; 1-3) have been isolated from organic extracts of a new Penicillium species (P. thiersii). Their structures, including absolute stereochemistry, were determined by analysis of NMR data and application of Mosher's method. Thiersindoles A-C are biogenetically related to the aflavinines, although the [6,6,5] tricyclic diterpenoid skeleton in compounds 1 and 2 is unprecedented in any of the known members of this class.

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