Divergent Anti-HBc Reactivities in HB-immune and Chronic HBsAg Carriers

We have monitored titers of anti-HBc antibodies in sera from acutely HBV-infected and chronic HBsAg carriers. Our data show that there is a divergence in the specificity of the antibodies in these two populations. We also present preliminary results showing that serum from HB-immune carriers contain antibodies that are multispecific and display autoimmune characteristics, reacting with human serum albumin.