[Experimental Provocation of Panic Attacks As a Human Experimental Model for Anxiety]

Overview

Journal Nervenarzt

Specialty Neurology

Date 2003 Sep 25

PMID 14504770

Citations 1

Authors

A Strohle

Affiliations

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Abstract

Diagnostic symptom provocation has a long tradition in medicine. In psychiatry, symptom provocation studies are used to study the pathophysiology and treatment of disorders. Sudden and unexpected panic attacks have a characteristic course and a typical pattern of somatic, cognitive, emotional, and behavioral symptoms. Beginning with the study of Pitts and McClure, who described the panicogenic activity of sodium lactate, the experimental induction of panic attacks with different challenges has been used to characterize the neurobiology of anxiety. Furthermore, experimentally induced panic attacks can be used to study possible new treatment approaches. The anxiolytic activity of atrial natriuretic peptide suggests that modulation of natriuretic peptide receptors with nonpeptidergic ligands may be a new treatment approach. Experimentally induced panic attacks are a tool to characterize the neurobiology of anxiety and panic and may be used to develop new treatment approaches.

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References

Bonn J, Harrison J, Rees L . Lactate infusion in the treatment of 'free-floating' anxiety. Can Psychiatr Assoc J. 1973; 18(1):41-6. DOI: 10.1177/070674377301800108. View

Strohle A, Kellner M, Yassouridis A, Holsboer F, Wiedemann K . Effect of flumazenil in lactate-sensitive patients with panic disorder. Am J Psychiatry. 1998; 155(5):610-2. DOI: 10.1176/ajp.155.5.610. View

Cameron O, Lee M, Curtis G, MCCANN D . Endocrine and physiological changes during "spontaneous" panic attacks. Psychoneuroendocrinology. 1987; 12(5):321-31. DOI: 10.1016/0306-4530(87)90061-8. View

Bradwejn J, Koszycki D . Imipramine antagonism of the panicogenic effects of cholecystokinin tetrapeptide in panic disorder patients. Am J Psychiatry. 1994; 151(2):261-3. DOI: 10.1176/ajp.151.2.261. View

Pitts Jr F, McCLURE Jr J . Lactate metabolism in anxiety neurosis. N Engl J Med. 1967; 277(25):1329-36. DOI: 10.1056/NEJM196712212772502. View

Gorman J, Fyer M, Goetz R, Askanazi J, Liebowitz M, Fyer A . Ventilatory physiology of patients with panic disorder. Arch Gen Psychiatry. 1988; 45(1):31-9. DOI: 10.1001/archpsyc.1988.01800250035006. View

Wiedemann K, Jahn H, Yassouridis A, Kellner M . Anxiolyticlike effects of atrial natriuretic peptide on cholecystokinin tetrapeptide-induced panic attacks: preliminary findings. Arch Gen Psychiatry. 2001; 58(4):371-7. DOI: 10.1001/archpsyc.58.4.371. View

Hunkeler W, Mohler H, Pieri L, Polc P, Bonetti E, Cumin R . Selective antagonists of benzodiazepines. Nature. 1981; 290(5806):514-6. DOI: 10.1038/290514a0. View

Kellner M, Herzog L, Yassouridis A, Holsboer F, Wiedemann K . Possible role of atrial natriuretic hormone in pituitary-adrenocortical unresponsiveness in lactate-induced panic. Am J Psychiatry. 1995; 152(9):1365-7. DOI: 10.1176/ajp.152.9.1365. View

10.

Breuning S, Ferguson D, Cullari S . Analysis of single, double-blind procedures, maintenance of placebo effects, and drug-induced dyskinesia with mentally retarded persons--a brief report [proceedings]. Psychopharmacol Bull. 1981; 17(1):122-3. View

11.

Targum S, Marshall L . Fenfluramine provocation of anxiety in patients with panic disorder. Psychiatry Res. 1989; 28(3):295-306. DOI: 10.1016/0165-1781(89)90210-2. View

12.

Kramer M, Cutler N, Ballenger J, PATTERSON W, MENDELS J, Chenault A . A placebo-controlled trial of L-365,260, a CCKB antagonist, in panic disorder. Biol Psychiatry. 1995; 37(7):462-6. DOI: 10.1016/0006-3223(94)00190-E. View

13.

Kellner M, Wiedemann K, Holsboer F . Atrial natriuretic factor inhibits the CRH-stimulated secretion of ACTH and cortisol in man. Life Sci. 1992; 50(24):1835-42. DOI: 10.1016/0024-3205(92)90543-x. View

14.

Steiger A, Guldner J, Lauer C, Meschenmoser C, Pollmacher T, Holsboer F . Flumazenil exerts intrinsic activity on sleep EEG and nocturnal hormone secretion in normal controls. Psychopharmacology (Berl). 1994; 113(3-4):334-8. DOI: 10.1007/BF02245206. View

15.

Lesoin F, Bousquet C, Thomas 3rd C, Quandalle P, RIBET M, Jomin M . Transient ischaemic attacks on patient with endothoracic goitre and congenital anomaly of the carotid arteries. Lancet. 1982; 2(8289):98. DOI: 10.1016/s0140-6736(82)91716-0. View

16.

Svensson T, Usdin T . Feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants: alpha-receptor mediation. Science. 1978; 202(4372):1089-91. DOI: 10.1126/science.213833. View

17.

Lesch K, Wiesmann M, Hoh A, Muller T, Osterheider M, Schulte H . 5-HT1A receptor-effector system responsivity in panic disorder. Psychopharmacology (Berl). 1992; 106(1):111-7. DOI: 10.1007/BF02253597. View

18.

Roy-Byrne P, Cowley D, Greenblatt D, Shader R, Hommer D . Reduced benzodiazepine sensitivity in panic disorder. Arch Gen Psychiatry. 1990; 47(6):534-8. DOI: 10.1001/archpsyc.1990.01810180034006. View

19.

De Montigny C . Cholecystokinin tetrapeptide induces panic-like attacks in healthy volunteers. Preliminary findings. Arch Gen Psychiatry. 1989; 46(6):511-7. DOI: 10.1001/archpsyc.1989.01810060031006. View

20.

Poggioli R, Vergoni A, Rasori E, Marrama D, Bertolini A . Behavioral effects of atriopeptin in rats. Neuropeptides. 1992; 22(3):149-54. DOI: 10.1016/0143-4179(92)90157-r. View