Vascularized Tissue Transfer for Closure of Irradiated Wounds After Soft Tissue Sarcoma Resection

Overview

Journal Ann Surg

Specialty General Surgery

Date 1992 Nov 1

PMID 1444651

Citations 19

Authors

W J Barwick

J A Goldberg

S P Scully

J M Harrelson

Affiliations

Soon will be listed here.

Abstract

During the years 1985 to 1989, 82 patients were included in the soft tissue sarcoma protocol. Preoperative irradiation (50-54 Gy) was performed in all patients before tumor extirpation. Microwave hyperthermia was performed in conjunction with radiation in patients who had gross tumor remaining after initial biopsy. Primary closure with vascularized tissue (flaps) in lieu of conventional wound closure by skin approximation led to less complications (19% versus 51%), fewer secondary procedures for wound closure (10% versus 35%), shorter average hospitalization (15 versus 48 days) and greater limb salvage rate (97% versus 91%). The authors conclude that vascularized tissue (flaps) for primary wound closure in irradiated tissue leads to improved wound healing, and should be considered the procedure of choice for heavily irradiated soft tissue sarcoma defects.

Citing Articles

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Postradiation Fractures after Combined Modality Treatment in Extremity Soft Tissue Sarcomas.

Bartelstein M, Yerramilli D, Christ A, Kenan S, Ogura K, Fujiwara T Sarcoma. 2021; 2021:8877567.

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Efficacy of hyperthermic isolated limb perfusion in the treatment of locally recurrent high-grade soft tissue sarcoma of the extremities.

Farzaliyev F, Touma A, Taeger G, Steinau H, Hardes J, Streitburger A World J Surg Oncol. 2020; 18(1):332.

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One-Stage Soft Tissue Reconstruction Following Sarcoma Excision: A Personalized Multidisciplinary Approach Called "Orthoplasty".

Angelini A, Tiengo C, Sonda R, Berizzi A, Bassetto F, Ruggieri P J Pers Med. 2020; 10(4).

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Surgical resection, intraoperative radiotherapy and immediate plastic reconstruction: A good option for the treatment of distal extremity soft tissue sarcomas.

Hanna S, Munhoz R, de Freitas Perina A, Goncalves M, da Costa F, Busnardo F Rep Pract Oncol Radiother. 2020; 25(6):919-926.

PMID: 33088227 PMC: 7550832. DOI: 10.1016/j.rpor.2020.09.008.

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