Morphometric Study of the Sensory Neuron and Peripheral Nerve Changes Induced by Chronic Cisplatin (DDP) Administration in Rats

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1992 Jan 1

PMID 1441917

Citations 55

Authors

G Cavaletti

G Tredici

P Marmiroli

M G Petruccioli

I Barajon

D Fabbrica

Affiliations

Soon will be listed here.

Abstract

We performed a morphological, morphometric and toxicological study on the spinal ganglia and peripheral nerves of the rat after chronic administration of cisplatin (cis-dichlorodiammineplatinum II; DDP) with two different schedules. Severe damage of the spinal ganglia neurons was demonstrated with predominant involvement of the nucleus and nucleolus associated with a decrease in the cell size. Morphological and morphometric changes also occurred in the sciatic and peroneal nerves with the features of axonopathy. All these changes were more marked in the group of rats which underwent the most intense DDP treatment and the tissue platinum concentrations were also higher in this group. This experimental model is the first available for chronic DDP administration in which concomitant spinal ganglia and peripheral nerve damage has been confirmed pathologically. Our study supports the hypothesis that DDP-induced peripheral nerve fiber degeneration may result from nuclear and nucleolar changes in the sensory ganglion cell perikaryon.

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References

Hadley D, Herr H . Peripheral neuropathy associated with cis-dichlorodiammineplatinum (II) treatment. Cancer. 1979; 44(6):2026-8. DOI: 10.1002/1097-0142(197912)44:6<2026::aid-cncr2820440610>3.0.co;2-1. View

Spencer P, Thomas P . Ultrastructural studies of the dying-back process. II. The sequestration and removal by Schwann cells and oligodendrocytes of organelles from normal and diseases axons. J Neurocytol. 1974; 3(6):763-83. DOI: 10.1007/BF01097197. View

Cavaletti G, Marzorati L, Bogliun G, Colombo N, Marzola M, Pittelli M . Cisplatin-induced peripheral neurotoxicity is dependent on total-dose intensity and single-dose intensity. Cancer. 1992; 69(1):203-7. DOI: 10.1002/1097-0142(19920101)69:1<203::aid-cncr2820690133>3.0.co;2-1. View

Rosenberg B . Fundamental studies with cisplatin. Cancer. 1985; 55(10):2303-l6. DOI: 10.1002/1097-0142(19850515)55:10<2303::aid-cncr2820551002>3.0.co;2-l. View

Ashraf M, Riggs J, Wearden S, Scotchel P . Prospective study of nerve conduction parameters and serum magnesium following cisplatin therapy. Gynecol Oncol. 1990; 37(1):29-33. DOI: 10.1016/0090-8258(90)90302-2. View

Mollman J . Cisplatin neurotoxicity. N Engl J Med. 1990; 322(2):126-7. DOI: 10.1056/NEJM199001113220210. View

Tomiwa K, Nolan C, CAVANAGH J . The effects of cisplatin on rat spinal ganglia: a study by light and electron microscopy and by morphometry. Acta Neuropathol. 1986; 69(3-4):295-308. DOI: 10.1007/BF00688308. View

Thompson S, Davis L, Kornfeld M, Hilgers R, Standefer J . Cisplatin neuropathy. Clinical, electrophysiologic, morphologic, and toxicologic studies. Cancer. 1984; 54(7):1269-75. DOI: 10.1002/1097-0142(19841001)54:7<1269::aid-cncr2820540707>3.0.co;2-9. View

Daugaard G, Petrera J, TROJABORG W . Electrophysiological study of the peripheral and central neurotoxic effect of cis-platin. Acta Neurol Scand. 1987; 76(2):86-93. DOI: 10.1111/j.1600-0404.1987.tb03551.x. View

10.

Kedar A, Cohen M, Freeman A . Peripheral neuropathy as a complication of cis-dichlorodiammineplatinum(II) treatment: a case report. Cancer Treat Rep. 1978; 62(5):819-21. View

11.

Riggs J, Ashraf M, Snyder R, Gutmann L . Prospective nerve conduction studies in cisplatin therapy. Ann Neurol. 1988; 23(1):92-4. DOI: 10.1002/ana.410230116. View

12.

Parti R, Wolf W . Quantitative subcellular distribution of platinum in rat tissues following i.v. bolus and i.v. infusion of cisplatin. Cancer Chemother Pharmacol. 1990; 26(3):188-92. DOI: 10.1007/BF02897197. View

13.

Roelofs R, Hrushesky W, Rogin J, Rosenberg L . Peripheral sensory neuropathy and cisplatin chemotherapy. Neurology. 1984; 34(7):934-8. DOI: 10.1212/wnl.34.7.934. View

14.

Terheggen P, van der Hoop R, Floot B, Gispen W . Cellular distribution of cis-diamminedichloroplatinum(II)-DNA binding in rat dorsal root spinal ganglia: effect of the neuroprotecting peptide ORG.2766. Toxicol Appl Pharmacol. 1989; 99(2):334-43. DOI: 10.1016/0041-008x(89)90015-x. View

15.

Muller L, Gerritsen van der Hoop R, Gispen W, Roubos E . Morphological and electrophysiological study of the effects of cisplatin and ORG.2766 on rat spinal ganglion neurons. Cancer Res. 1990; 50(8):2437-42. View

16.

Boogerd W, Ten Bokkel Huinink W, Dalesio O, Hoppenbrouwers W, van der Sande J . Cisplatin induced neuropathy: central, peripheral and autonomic nerve involvement. J Neurooncol. 1990; 9(3):255-63. DOI: 10.1007/BF02341156. View

17.

de Koning P, Neijt J, Jennekens F, Gispen W . Evaluation of cis-diamminedichloroplatinum (II) (cisplatin) neurotoxicity in rats. Toxicol Appl Pharmacol. 1987; 89(1):81-7. DOI: 10.1016/0041-008x(87)90178-5. View

18.

Cornblath D, Brown M . Influence of malnutrition on developing rat peripheral nerves. Exp Neurol. 1988; 99(2):403-11. DOI: 10.1016/0014-4886(88)90157-4. View

19.

Cavaletti G, Tredici G, Pizzini G, Minoia A . Tissue platinum concentrations and cisplatin schedules. Lancet. 1990; 336(8721):1003. DOI: 10.1016/0140-6736(90)92462-q. View

20.

Cavaletti G, Petruccioli M, Tredici G, Marmiroli P, Barajon I, Fabbrica D . Effects of repeated administration of low doses of cisplatin on the rat nervous system. Int J Tissue React. 1991; 13(3):151-7. View