The Pathogenetic Aspects of Spondyloarthropathies from the Point of View of HLA-B27

Overview

Journal Rheumatol Int

Specialty Rheumatology

Date 1992 Jan 1

PMID 1439478

Citations 3

Authors

H Kellner

D Yu

Affiliations

Soon will be listed here.

Abstract

The association of HLA-B27 and seronegative spondyloarthropathies, especially ankylosing spondylitis has been known for almost two decades. The spontaneous development of spondyloarthropathy like joint disease in HLA-B27 transgenic rats verifies the suspicion that the HLA-B27 antigens are directly responsible for disease development. With the recently revealed crystal structure of HLA-B27 and understanding of the class I molecule in general, a new hypothesis can be formulated based on the assumption that the pathogenesis of these diseases is a subversion of the physiological function.

Citing Articles

Ankylosing spondylitis in rheumatology patients in Ouagadougou (Burkina Faso).

Ouedraogo D, Tieno H, Kabore H, Palazzo E, Meyer O, Drabo J Clin Rheumatol. 2009; 28(12):1375-7.

PMID: 19727919 DOI: 10.1007/s10067-009-1250-8.

HLA-B27 determination using serological methods. A comparison of enzyme immunoassay and a microlymphocytotoxic test with flow cytometry and a molecular biological assay.

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The pathogenesis of HLA-B27 associated arthritis: lessons from the B27 crystal.

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