The Effect of Ascorbic Acid on Cadmium Accumulation in Guinea Pig Tissues

Overview

Journal Experientia

Specialty Science

Date 1992 Oct 15

PMID 1426151

Citations 3

Authors

J Kadrabova

A Madaric

E Ginter

Affiliations

Soon will be listed here.

Abstract

Accumulation of cadmium in organs of guinea pigs after subchronic oral cadmium treatment (1 mg Cd/animal/24 h) was in the following order: kidneys > liver > heart > testes > brain. The preventive effects of high doses of ascorbic acid (AA) against cadmium deposition were more pronounced in the testes, heart and brain, and in the kidney only after short-term cadmium treatment. Ascorbic acid had no protective effect on cadmium accumulation in the liver.

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References

Ginter E . Marginal vitamin C deficiency, lipid metabolism, and atherogenesis. Adv Lipid Res. 1978; 16:167-220. DOI: 10.1016/b978-0-12-024916-9.50009-3. View

Nomiyama K . Recent progress and perspectives in cadmium health effects studies. Sci Total Environ. 1980; 14(3):199-232. DOI: 10.1016/0048-9697(80)90024-8. View

Engvall J, Perk J . Prevalence of hypertension among cadmium-exposed workers. Arch Environ Health. 1985; 40(3):185-90. DOI: 10.1080/00039896.1985.10545915. View

Smith J, HODGES R . Serum levels of vitamin C in relation to dietary and supplemental intake of vitamin C in smokers and nonsmokers. Ann N Y Acad Sci. 1987; 498:144-52. DOI: 10.1111/j.1749-6632.1987.tb23758.x. View

Fox M, Fry Jr B, Harland B, SCHERTEL M, Weeks C . Effect of ascorbic acid on cadmium toxicity in the young coturnix. J Nutr. 1971; 101(10):1295-305. DOI: 10.1093/jn/101.10.1295. View

Onosaka S, Kawakami D, Min K, Tanaka K . Induced synthesis of metallothionein by ascorbic acid in mouse liver. Toxicology. 1987; 43(3):251-9. DOI: 10.1016/0300-483x(87)90084-9. View

Buckley B, Bassett D . Pulmonary cadmium oxide toxicity in the rat. J Toxicol Environ Health. 1987; 21(1-2):233-50. DOI: 10.1080/15287398709531015. View

Thun M, Osorio A, Schober S, Hannon W, Lewis B, Halperin W . Nephropathy in cadmium workers: assessment of risk from airborne occupational exposure to cadmium. Br J Ind Med. 1989; 46(10):689-97. PMC: 1009850. DOI: 10.1136/oem.46.10.689. View

Nordberg G . Modulation of metal toxicity by metallothionein. Biol Trace Elem Res. 1989; 21:131-5. DOI: 10.1007/BF02917245. View

10.

GLAUSER S, BELLO C, GLAUSER E . Blood-cadmium levels in normotensive and untreated hypertensive humans. Lancet. 1976; 1(7962):717-8. DOI: 10.1016/s0140-6736(76)93091-9. View

11.

Fox M . Effects of dietary mineral levels on metabolism and requirements. Neurotoxicology. 1983; 4(3):113-20. View

12.

Groten J, Sinkeldam E, Muys T, Luten J, van Bladeren P . Interaction of dietary Ca, P, Mg, Mn, Cu, Fe, Zn and Se with the accumulation and oral toxicity of cadmium in rats. Food Chem Toxicol. 1991; 29(4):249-58. DOI: 10.1016/0278-6915(91)90022-y. View

13.

Geiger H, Bahner U, Anderes S, Schaefer R, Schaller K . Cadmium and renal hypertension. J Hum Hypertens. 1989; 3(1):23-7. View

14.

Hamer D . Metallothionein. Annu Rev Biochem. 1986; 55:913-51. DOI: 10.1146/annurev.bi.55.070186.004405. View

15.

Fox M, Jacobs R, Jones A, Fry Jr B, Stone C . Effects of vitamin C and iron and cadmium metabolism. Ann N Y Acad Sci. 1980; 355:249-61. DOI: 10.1111/j.1749-6632.1980.tb21343.x. View

16.

Dudley R, Svoboda D, Klaassen C . Acute exposure to cadmium causes severe liver injury in rats. Toxicol Appl Pharmacol. 1982; 65(2):302-13. DOI: 10.1016/0041-008x(82)90013-8. View

17.

Suzuki T, Yoshida A . Long-term effectiveness of dietary iron and ascorbic acid in the prevention and cure of cadmium toxicity in rats. Am J Clin Nutr. 1978; 31(9):1491-8. DOI: 10.1093/ajcn/31.9.1491. View

18.

Brown A, Taylor A . Applications of a slotted quartz tube and flame atomic-absorption spectrometry to the analysis of biological samples. Analyst. 1985; 110(6):579-82. DOI: 10.1039/an9851000579. View