Immunhistochemical and Electron Microscope Analysis of Adenomas of the Thyroid Gland. I. A Comparative Investigation of Hot and Cold Nodules

Overview

Journal Virchows Arch A Pathol Anat Histol

Specialty Pathology

Date 1977 Jul 11

PMID 142353

Citations 8

Authors

H Dralle

W Bocker

Affiliations

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Abstract

Histologic, immunhistochemical and electron microscopic changes in 8 cases of scintigraphically proven autonomous thyroid adenomas are described and compared with non-functioning adenomas. Adenomas with a light microscopic appearance suggesting autonomy show follicles which are mainly small or normal sized and lined by columnar thyroid cells with a partly vacuolated and eosinophilic cytoplasm. Immunhistochemically a high content of thyroglobulin corresponds to the amount of rough endoplasmatic reticulum. Typical ultrastructural criteria are a well developed cytocavitary network, numerous mainly apically localized lysosomes, prominent Golgi fields with sprouting vesicles and autophagic vacuoles. The cell surface is, when compared to non-functioning adenomas, enlared apically by numerous long microvilli and basally by deep infoldings. On contrast to experimentally TSH-stimulated animal thyroids, colloid droplets and pseudopodia are rare. The morphological findings are compared with recent biochemical results and the diagnostic value of electron microscopy is discussed.

Citing Articles

Immunohistochemical analysis of thyroglobulin synthesis in thyroid carcinomas.

Bocker W, Dralle H, HUSSELMANN H, Bay V, Brassow M Virchows Arch A Pathol Anat Histol. 1980; 385(2):187-200.

PMID: 7355570 DOI: 10.1007/BF00427404.

[Thyroglobulin immunohistochemistry: new aspects of pathophysiology and differential diagnosis of benign and malignant goitre (author's transl)].

Dralle H, Bocker W Langenbecks Arch Chir. 1982; 356(3):205-12.

PMID: 7070163 DOI: 10.1007/BF01261758.

Simultaneous detection of thyroglobulin (Tg), thyroxine (T4), and Triiodothyronine (T3) in nontoxic thyroid tumors by the immunoperoxidase method.

Kawaoi A, Okano T, Nemoto N, Shiina Y, Shikata T Am J Pathol. 1982; 108(1):39-49.

PMID: 7046455 PMC: 1916028.

Production of thyroxine (T4) and triiodothyronine (T3) in nontoxic thyroid tumors. An immunohistochemical study.

Kawaoi A, Okano T, Nemoto N, Shikata T Virchows Arch A Pathol Anat Histol. 1981; 390(3):249-57.

PMID: 7025437 DOI: 10.1007/BF00496557.

Immunohistochemical analysis of thyroglobulin and keratin in benign and malignant thyroid tumours.

Permanetter W, Nathrath W, Lohrs U Virchows Arch A Pathol Anat Histopathol. 1982; 398(2):221-8.

PMID: 6187120 DOI: 10.1007/BF00618871.

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