GENETIC RECOMBINATION BETWEEN THE RESISTANCE TRANSFER FACTOR AND THE CHROMOSOME OF ESCHIERICHIA COLI

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1964 Jun 1

PMID 14188711

Citations 7

Authors

H S GINOZA

R B Painter

Affiliations

Soon will be listed here.

Abstract

Ginoza, Herbert S. (National Aeronautics and Space Administration, Moffett Field, Calif.), and Robert B. Painter. Genetic recombination between the resistance transfer factor and the chromosome of Escherichia coli. J. Bacteriol. 87:1339-1345. 1964.-Genetic instability for high-level streptomycin and chloramphenicol resistance was observed in several strains of Escherichia coli infected with the resistance transfer factor (RTF) episome. The altered site was always found on the chromosome, and the resistance characteristics were similar to, if not identical with, the corresponding determinant found on the episome. The high-level drug resistance phenotype was ascribed to two separate loci acting cooperatively within the host. The instability phenomenon had been attributed to a genetic exchange mechanism in which the chromosome copies the drug-resistance information from the episome, thus giving rise to a diploid homogenote for this segment. In a reciprocal exchange system, the tetracycline-resistance marker on the chromosome was shown to recombine with the RTF episome lacking this information.

Citing Articles

GENETIC INSTABILITY IN ESCHERICHIA COLI.

SCHWARTZ N J Bacteriol. 1965; 89:712-7.

PMID: 14273650 PMC: 277526. DOI: 10.1128/jb.89.3.712-717.1965.

Interaction between R-factors and the host cells. I. Lethal interference between R-factor determined streptomycin resistance and streptomycin dependence in Proteus mirabilis.

Hofemeister J, Bohme H Mol Gen Genet. 1968; 103(3):258-65.

PMID: 5713665 DOI: 10.1007/BF00273697.

Plasmid-linked resistance to inorganic salts in Staphylococcus aureus.

Novick R, Roth C J Bacteriol. 1968; 95(4):1335-42.

PMID: 5646621 PMC: 315091. DOI: 10.1128/jb.95.4.1335-1342.1968.

Sensitivity of Escherichia coli to atabrine conferred by R factor and its potential clinical significance.

Yoshikawa M, SEVAG M J Bacteriol. 1967; 93(1):245-53.

PMID: 5335891 PMC: 314995. DOI: 10.1128/jb.93.1.245-253.1967.

Some characteristics of the resistance transfer factor (RTF) episome as determined by inactivation with tritium, P32, and gamma radiation.

Painter R, GINOZA H Biophys J. 1966; 6(2):153-62.

PMID: 5335449 PMC: 1367806. DOI: 10.1016/S0006-3495(66)86647-X.

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