Effects of Interleukin-6 on the Metabolism of Connective Tissue Components in Rheumatoid Synovial Fibroblasts

Overview

Journal Arthritis Rheum

Specialty Rheumatology

Date 1992 Oct 1

PMID 1418006

Citations 28

Authors

A Ito

Y Itoh

Y Sasaguri

M Morimatsu

Y Mori

Affiliations

Soon will be listed here.

Abstract

Objective: High levels of interleukin-6 (IL-6) have been found in the synovial fluid of patients with rheumatoid arthritis (RA). We undertook the present study to investigate the role of IL-6 in this disease.

Methods: We examined the effects of IL-6, in comparison with IL-1, on the biosynthesis of extracellular matrix macromolecules and of matrix-degrading proteinases in rheumatoid synovial fibroblasts.

Results: In rheumatoid synovial fibroblasts, IL-6 by itself enhanced the production of plasminogen activator, its inhibitor, and tissue inhibitor of metalloproteinases, whereas it did not modulate the biosynthesis of precursor of matrix metalloproteinase 1 (proMMP-1) (tissue collagenase), proMMP-3 (stromelysin), or connective tissue components. However, IL-1-induced production of proMMP-1 and proMMP-3 was preferentially augmented by IL-6.

Conclusion: These results suggest that in RA, IL-6 may participate along with IL-1 in fine tuning of the catabolism of connective tissue components, by modulating the balance between connective tissue-degrading enzymes and their inhibitors.

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