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A QUANTITATIVE STUDY OF THE EFFECT OF COCAINE ON THE RESPONSE OF THE CAT NICTITATING MEMBRANE TO NERVE STIMULATION AND TO INJECTED NORADRENALINE

Overview
Journal Br J Pharmacol Chemother
Specialty Pharmacology
Date 1964 Feb 1
PMID 14126058
Citations 21
Authors
W Haefely
A HUERLIMANN
H Thoenen
Affiliations
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Abstract

Results are reported of a quantitative study of the potentiating effect of cocaine on the responses of the cat nictitating membrane to intravenously and intra-arterially injected noradrenaline, as well as to different types of sympathetic nerve stimulation. Responses of the membrane to noradrenaline were potentiated more with intravenous than with close-arterial injections. From studies of the responses of the nictitating membrane to various forms of sympathetic nerve stimulation before and after injection of cocaine, conclusions are drawn as to the extent to which the transmitter amine liberated by nerve activity is normally removed and its effect thereby limited in duration and extent. This uptake was greatest at low stimulus frequencies. The mechanism by which cocaine potentiates sympathetic responses is discussed.

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Release of noradrenaline by one pulse: modulation of such release by alpha-adrenoceptor antagonists and uptake blockers.

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Effects of hypothermia and anoxia on retention of noradrenaline by the cat perfused heart.

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Relation between the rate of stimulation and the quantity of noradrenaline liberated from sympathetic nerve endings in the isolated perfused spleen of the cat.

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References
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Muscholl E . Effect of cocaine and related drugs on the uptake of noradrenaline by heart and spleen. Br J Pharmacol Chemother. 1961; 16:352-9. PMC: 1482029. DOI: 10.1111/j.1476-5381.1961.tb01095.x. View
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Haefely W, HUERLIMANN A, Thoenen H . THE RESPONSES TO TYRAMINE OF THE NORMAL AND DENERVATED NICTITATING MEMBRANE OF THE CAT: ANALYSIS OF THE MECHANISMS AND SITES OF ACTION. Br J Pharmacol Chemother. 1963; 21:27-38. PMC: 1703853. DOI: 10.1111/j.1476-5381.1963.tb01498.x. View