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Transmural Distribution of Myocardial Blood Flow and of Coronary Reserve in Canine Left Ventricular Hypertrophy

Overview
Journal Basic Res Cardiol
Specialty Cardiology & Vascular Diseases
Date 1977 Mar 1
PMID 140675
Citations 22
Authors
J Holtz
W V Restorff
P BARD
E Bassenge
Affiliations
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Abstract

Left ventricular hypertrophy was induced by banding of the ascending aorta in pupies at the age of 6 weeks. At the age of one year left ventricular weight per body weight was increased by 87% compared to control litter mates. While myocardial perfusion and myocardial oxygen consumption per 100 g were identical in the hypertrophy and control group, there was a significantly diminshed ratio of subendocardial/subepicardial flow in the hypertrophy group during moderate exercise. With maximal coronary dilation subendocardial diastolic resistance (mm Hg/ml-min-1 per 100 g) was 0.16 +/- 0.03 in the control group and 0.26 +/- 0.03 in the hypertrophy group. This diminished coronary reserve indicates an insufficient growth of the vascular bed in these hypertrophied hearts.

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