THE MODE OF ACTION OF NEOSTIGMINE AND PHYSOSTIGMINE ON THE GUINEA-PIG TRACHEALIS MUSCLE

Overview

Journal Br J Pharmacol Chemother

Specialty Pharmacology

Date 1963 Aug 1

PMID 14066138

Citations 16

Authors

R F CARLYLE

Affiliations

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Abstract

Neostigmine (2.2 mug/ml.) or physostigmine (3.3 mug/ml.) contracted guinea-pig isolated tracheal chains. The anticholinesterase diisopropylphosphodiamidic fluoride (mipafox) itself caused no contractile response even in concentrations of 100 mug/ml., yet neostigmine or physostigmine still caused contractions after treatment with mipafox. The responses were abolished by hyoscine or atropine. Local anaesthetics, cooling, ionic changes and hemicholinium, all known to inhibit the release of acetylcholine from nerve endings, abolished or much reduced the responses. It seems that the contractile response to physostigmine or neostigmine does not depend on their anticholinesterase activity, but on their ability to release acetylcholine from postganglionic parasympathetic nerve endings.

Citing Articles

THE RESPONSES OF THE GUINEA-PIG ISOLATED INTACT TRACHEA TO TRANSMURAL STIMULATION AND THE RELEASE OF AN ACETYLCHOLINE-LIKE SUBSTANCE UNDER CONDITIONS OF REST AND STIMULATION.

CARLYLE R Br J Pharmacol Chemother. 1964; 22:126-36.

PMID: 14126042 PMC: 1703898. DOI: 10.1111/j.1476-5381.1964.tb01550.x.

THE ORIGIN OF THE ACETYLCHOLINE RELEASED SPONTANEOUSLY FROM THE GUINEA-PIG ISOLATED ILEUM.

Johnson E Br J Pharmacol Chemother. 1963; 21:555-68.

PMID: 14110755 PMC: 1703892. DOI: 10.1111/j.1476-5381.1963.tb02023.x.

THE SITE OF THE 5-HYDROXYTRYPTAMINE RECEPTOR ON THE INTRAMURAL NERVOUS PLEXUS OF THE GUINEA-PIG ISOLATED ILEUM.

Brownlee G, Johnson E Br J Pharmacol Chemother. 1963; 21:306-22.

PMID: 14081661 PMC: 1703842. DOI: 10.1111/j.1476-5381.1963.tb01529.x.

Different properties of the bradycardia produced by neostigmine and edrophonium in the cat.

Backman S, Stein R, Blank D, Collier B, POLOSA C Can J Anaesth. 1996; 43(7):731-40.

PMID: 8807181 DOI: 10.1007/BF03017959.

Degradation of acetylcholine in human airways: role of butyrylcholinesterase.

Norel X, Angrisani M, Labat C, Gorenne I, Dulmet E, Rossi F Br J Pharmacol. 1993; 108(4):914-9.

PMID: 8485630 PMC: 1908169. DOI: 10.1111/j.1476-5381.1993.tb13486.x.

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