POLYPEPTIDE CHAINS OF RABBIT GAMMAGLOBULIN

Overview

Journal Science

Specialty Science

Date 1963 Oct 18

PMID 14056707

Citations 11

Authors

P A Small Jr

J E KEHN

M E Lamm

Affiliations

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Abstract

Rabbit gamma globulin has been extensively reduced, and its polypeptide chains separated by gel filtration on Sephadex G-200 in SM guanidine hydrochloride. The larger H (or A) chains make up two-thirds of the molecule and have a molecular weight of approximately 55,000 each. The smaller L (or B) chains account for the other one-third and have a molecular weight of approximately 25,000 each. The data are consistent with a model of the gamma globulin molecule that has two H and two L chains.

Citing Articles

RECOMBINATION OF ANTIBODY POLYPEPTIDE CHAINS IN THE PRESENCE OF ANTIGEN.

Metzger H, Mannik M J Exp Med. 1964; 120:765-82.

PMID: 14247718 PMC: 2137869. DOI: 10.1084/jem.120.5.765.

A MODEL FOR THE 7S ANTIBODY MOLECULE.

Edelman G, Gally J Proc Natl Acad Sci U S A. 1964; 51:846-53.

PMID: 14173001 PMC: 300172. DOI: 10.1073/pnas.51.5.846.

RECONSTITUTION OF 7S MOLECULES FROM L AND H POLYPEPTIDE CHAINS OF ANTIBODIES AND GAMMA-GLOBULINS.

Olins D, Edelman G J Exp Med. 1964; 119:789-815.

PMID: 14157031 PMC: 2137744. DOI: 10.1084/jem.119.5.789.

Phylogenetic origins of antibody structure. 3. Antibodies in the primary immune response of the sea lamprey, Petromyzon marinus.

Marchalonis J, Edelman G J Exp Med. 1968; 127(5):891-914.

PMID: 5690272 PMC: 2138490. DOI: 10.1084/jem.127.5.891.

Comparison of the cysteine-containing peptides from rabbit anti-tobacco mosaic virus antibody and non-specific immunoglobulin G by peptide mapping.

Szpirer C Immunology. 1971; 20(2):137-49.

PMID: 5548566 PMC: 1455794.