HEMIN BIOSYNTHESIS IN HAEMOPHILUS

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1963 Apr 1

PMID 14044953

Citations 45

Authors

D C White

S Granick

Affiliations

Soon will be listed here.

Abstract

White, David C. (The Rockefeller Institute, New York, N.Y.) and S. Granick. Hemin biosynthesis in Haemophilus. J. Bacteriol. 85:842-850. 1963.-Hemin-independent Haemophilus species have been shown to form hemin by the classical hemin biosynthetic pathway. Three distinct species of Haemophilus [H. influenzae, H. aegyptius, and H. canis (H. haemoglobinophilus)] all lost the enzymatic capacities to convert delta-aminolevulinic acid to protoporphyrin, which accounts for their dependence on hemin for growth. The strain of H. aegyptus tested cannot form hemin from protoporphyrin, can be transformed with deoxyribonucleic acid (DNA) from H. influenzae, and the resultant progeny have the enzymatic activity to convert protoporphyrin to hemin. Attempts to transform these species to hemin independence with DNA from hemin-independent H. parainfluenzae are unsuccessful under conditions where streptomycin resistance is readily transformed.

Citing Articles

Sedimentary Cobalt Protoporphyrin as a Potential Precursor of Prosthetic Heme Group for Bacteria Inhabiting Fossil Organic Matter-Rich Shale Rock.

Stasiuk R, Matlakowska R Biomolecules. 2021; 11(12).

PMID: 34944556 PMC: 8699415. DOI: 10.3390/biom11121913.

Biosynthesis of Tetrapyrrole Cofactors by Bacterial Community Inhabiting Porphyrine-Containing Shale Rock (Fore-Sudetic Monocline).

Stasiuk R, Krucon T, Matlakowska R Molecules. 2021; 26(21).

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In Vitro Anti-NTHi Activity of Haemophilin-Producing Strains of .

Atto B, Latham R, Kunde D, Gell D, Tristram S Pathogens. 2020; 9(4).

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Novel antimicrobial activities of a peptide derived from a Japanese soybean fermented food, Natto, against Streptococcus pneumoniae and Bacillus subtilis group strains.

Kitagawa M, Shiraishi T, Yamamoto S, Kutomi R, Ohkoshi Y, Sato T AMB Express. 2017; 7(1):127.

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The Detection of Hemin-Binding Proteins in Riemerella anatipestifer CH-1.

Liao H, Liu M, Cheng X, Zhu D, Wang M, Jia R Curr Microbiol. 2015; 72(2):152-158.

PMID: 26542531 DOI: 10.1007/s00284-015-0932-5.

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