Actions of Bretylium and Guanethidine on the Uptake and Release of [3H]-noradrenaline

Overview

Journal Br J Pharmacol Chemother

Specialty Pharmacology

Date 1962 Feb 1

PMID 14036196

Citations 38

Authors

G Hertting

J Axelrod

R W PATRICK

Affiliations

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Abstract

The effect of bretylium and guanethidine has been studied on the uptake and the spontaneous and reserpine-induced release of [(3)H]-noradrenaline in the rat heart and in the splenic nerve endings of the cat. Bretylium and guanethidine inhibited the uptake by the heart of circulating [(3)H]-noradrenaline. Bretylium blocked spontaneous and reserpine-induced release of [(3)H]-noradrenaline, while guanethidine caused release and partially antagonized the reserpine-induced release. Both compounds produced a transient liberation of [(3)H]-noradrenaline from splenic nerves, but blocked the release of the [(3)H]-catechol amine following stimulation of the splenic nerve.

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