Article: Action of sympathomimetic drugs on the isolated junction of the bile duct and duodenum

The actions of adrenaline, noradrenaline and phenylephrine were studied both on the terminal tract of bile duct (prepared as spiral strips or intact) and on the adjacent duodenum taken from the calf and the cat. These amines contract the terminal bile duct and relax the duodenum. Furthermore, on the basis of the action of some adrenaline antagonists, the hypothesis is advanced that there are alpha-receptors which mediate contraction of muscle in the sphincterial zone of the bile duct.

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References

1.

Crema A, Benzi G, Berte F . The action of some natural substances on the terminal portion of the common bile duct isolated "in toto". Arch Int Pharmacodyn Ther. 1962; 137:307-17. View

2.

Munro A . The effect of adrenaline on the guinea-pig intestine. J Physiol. 1951; 112(1-2):84-94. PMC: 1393056. DOI: 10.1113/jphysiol.1951.sp004510. View

3.

ERDMANN W, HENNE H . [Spasmolytic effects on Oddi's sphincter]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1953; 218(6):462-78. View

4.

Levy B, AHLQUIST R . An analysis of adrenergic blocking activity. J Pharmacol Exp Ther. 1961; 133:202-10. View

5.

Hermansen K . The effect of adrenaline, noradrenaline and isoprenaline on the guinea-pig uterus. Br J Pharmacol Chemother. 1961; 16:116-28. PMC: 1482006. DOI: 10.1111/j.1476-5381.1961.tb00304.x. View

6.

Crema A, Benzi G . [Behavior in vitro of Oddi's sphincter of animals]. Arch Fisiol. 1961; 60:374-86. View

7.

FOGLIATI A, CIOCATTO E, CATTANEO A, Giudice P . [Modifications in bile duct tone under the action of certain drugs; experimental research and biliary manometry]. Arch Mal Appar Dig Mal Nutr. 1954; 43(4):428-44. View

8.

POILLEUX F, GOIDIN , NICHOLAIDIS . [Functional biliary dystonia. Role of the right pneumogastric nerve; experimental study and surgical inferences]. Presse Med (1893). 1952; 60(10):196-200. View

9.

MENGUY R, HALLENBECK G, BOLLMAN J, GRINDLAY J . Intraductal pressures and sphincteric resistance in canine pancreatic and biliary ducts after various stimuli. Surg Gynecol Obstet. 1958; 106(3):306-20. View

10.

LUDUENA F . Smooth muscle contracting effects of levo-N-isopropl arterenol and adrenolytic action of its dextroisomer. Arch Int Pharmacodyn Ther. 1962; 137:155-65. View

11.

DE LA MATA R, Penna M, AVIADO D . Reversal of sympathomimetic bronchodilation by dichloroisoproterenol. J Pharmacol Exp Ther. 1962; 135:197-203. View

12.

GRANSER G, Hertting G, RISSEL E, Wewalka F . [Research on the response of Oddi's sphincter to various drugs]. Arch Int Pharmacodyn Ther. 1956; 105(3-4):389-402. View

13.

Thompson J . Studies on the responses of the isolated nictitating membrane of the cat. J Physiol. 1958; 141(1):46-72. PMC: 1358815. DOI: 10.1113/jphysiol.1958.sp005954. View

Action of Sympathomimetic Drugs on the Isolated Junction of the Bile Duct and Duodenum