Tarichatoxin: Isolation and Purification

Overview

Journal Science

Specialty Science

Date 1963 Apr 19

PMID 14016021

Citations 15

Authors

M S Brown

H S MOSHER

Affiliations

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Abstract

The potent neurotoxin occurring in the embryos of the California newt, Taricha torosa, has been obtained in crystalline form. With a lethal subcutaneous dose of approximately 0.14 micrograms for a 20-gram mouse, it is, along with saxitoxin and tetrodotoxin, one of the most toxic nonprotein substances known.

Citing Articles

Tetrodotoxin and the state-of-the-art progress of its associated analytical methods.

Mi W, Liu S Front Microbiol. 2024; 15:1413741.

PMID: 39290516 PMC: 11407752. DOI: 10.3389/fmicb.2024.1413741.

Where Does All the Poison Go? Investigating Toxicokinetics of Newt (Taricha) Tetrodotoxin (TTX) in Garter Snakes (Thamnophis).

Robinson K, Moniz H, Stokes A, Feldman C J Chem Ecol. 2024; 50(9-10):489-502.

PMID: 38842636 DOI: 10.1007/s10886-024-01517-7.

Coevolution with toxic prey produces functional trade-offs in sodium channels of predatory snakes.

Del Carlo R, Reimche J, Moniz H, Hague M, Agarwal S, Brodie 3rd E bioRxiv. 2023; .

PMID: 38106015 PMC: 10723449. DOI: 10.1101/2023.12.08.570760.

An Overview of the Anatomical Distribution of Tetrodotoxin in Animals.

Melnikova D, Magarlamov T Toxins (Basel). 2022; 14(8).

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The Acute Toxicity of Tetrodotoxin and Tetrodotoxin⁻Saxitoxin Mixtures to Mice by Various Routes of Administration.

Finch S, Boundy M, Harwood D Toxins (Basel). 2018; 10(11).

PMID: 30360529 PMC: 6266834. DOI: 10.3390/toxins10110423.