Expression of Ki-67 Nuclear Antigen in B and T Cell Lymphoproliferative Disorders

Overview

Journal J Clin Pathol

Specialty Pathology

Date 1992 Aug 1

PMID 1401173

Citations 2

Authors

N de Melo

E Matutes

I Cordone

R Morilla

D Catovksy

Affiliations

Soon will be listed here.

Abstract

Aims: To determine whether the proliferation rates of tumour cells may relate to prognosis and reflect disease activity.

Methods: Blood mononuclear cells from 155 patients with B cell (n = 120) or T cell (n = 35) chronic lymphoproliferative disorders were tested with the monoclonal antibody Ki-67 by indirect immunoperoxidase or immunoalkaline phosphatase techniques. B cell diseases included chronic lymphocytic leukaemia (CLL), CLL in prolymphocytic transformation (CLL/PL), prolymphocytic leukaemia (B-PLL) and non-Hodgkin's lymphoma (B-NHL) in leukaemic phase. The T cell diseases comprised large granular lymphocyte (LGL) leukaemia, T-PLL, and T-NHL.

Results: These showed significantly higher proportions of Ki-67 positive cells in T cell (11.2%) than in B cell (2.9%) disorders (p < 0.001). The highest values were found in NHL of both B and T cell types, particularly when low grade disease transformed to high grade. The lowest percentages of Ki-67 positive cells were found in CLL (1.4%) and LGL leukaemia (1.7%); intermediate values were seen in B PLL (3.3%) and T PLL (5.8%).

Conclusions: There is a positive correlation between prognosis and proliferation rates in chronic B and T cell lymphoproliferative disorders. Estimation of Ki-67 in circulating leukaemic cells could be used to determine prognosis in low grade malignancies.

Citing Articles

Circulating Ki-67 index in plasma as a biomarker and prognostic indicator in chronic lymphocytic leukemia.

Bruey J, Kantarjian H, Ma W, Estrov Z, Yeh C, Donahue A Leuk Res. 2010; 34(10):1320-4.

PMID: 20362333 PMC: 4108997. DOI: 10.1016/j.leukres.2010.03.010.

Prognostic significance of cell proliferation and apoptosis-regulating proteins in Epstein-Barr Virus positive and negative pediatric non-Hodgkin's lymphoma.

Aktas S, Kargi A, Olgun N, Diniz G, Erbay A, Vergin C Pathol Oncol Res. 2008; 15(3):345-50.

PMID: 19048401 DOI: 10.1007/s12253-008-9127-8.

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