Effect of Guanethidine, Hemicholinium and Mebutamate on the Hypertensive Response to Eserine and Catechol Amines

Overview

Journal Br J Pharmacol Chemother

Specialty Pharmacology

Date 1962 Dec 1

PMID 13996274

Citations 6

Authors

V VARAGIC

N VOJVODIC

Affiliations

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Abstract

Guanethidine, hemicholinium and mebutamate were used to study the site and mechanism of the hypertensive response to eserine in the rat. Guanethidine was found to block very effectively the hypertensive effect of eserine and to produce at the same time a very strong potentiation of the response to catechol amines. Hemicholinium, after a certain latent period, also blocked the effect of eserine, at the same time leaving the response to adrenaline and noradrenaline intact. Mebutamate was also found to block the effect of eserine. The results of the present experiments suggest that eserine produces a central adrenergic activation in the rat.

Citing Articles

THE MECHANISM OF THE PRESSOR RESPONSES TO PHYSOSTIGMINE IN THE RAT AND THEIR MODIFICATION BY MEBUTAMATE AND AMYLOBARBITONE.

DELLABELLA D, Gandini A, Preti M Br J Pharmacol Chemother. 1964; 23:540-51.

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The action of adrenergic neurone blocking agents and other drugs on the pressor responses of various agents in the anaesthetized rat.

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Oxotremorine-induced hypertension in the anaesthetized rat.

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Strain differences in the inhibition by hemicholinium-3 of the pressor response to intraventricular injection of neostigmine in rats.

Brezenoff H, Rusin J Br J Pharmacol. 1974; 51(2):301-3.

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[Modification of the eserine pressor effect by propranolol].

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PMID: 4226515

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