Differential Effects of Bismuth and Salicylate Salts on the Antibiotic Susceptibility of Pseudomonas Aeruginosa

Overview

Journal Eur J Clin Microbiol Infect Dis

Publisher Springer

Specialties Infectious Diseases
Microbiology

Date 1992 Feb 1

PMID 1396732

Citations 5

Authors

P Domenico

R OLeary

B A Cunha

Affiliations

Soon will be listed here.

Abstract

The influence of salicylate or bismuth salts on antibiotic action against Pseudomonas aeruginosa was assessed in broth cultures. Sodium salicylate (2.5 mM) had no significant effect on the activity of any antibiotic tested. In contrast, bismuth compounds (0.5 mM) produced a significant change in the inhibitory activity of several antibiotics against all strains. Bismuth salts reduced imipenem activity by up to 20-fold, enhanced gentamicin or amikacin activity three to five-fold, and enhanced cefpirome or cefepime activity by as much as 10-fold against antibiotic-sensitive and resistant strains. Bismuth salts had little effect on cefoperazone, ceftazidime, or mezlocillin activity. Combining bismuth salts with aminoglycosides or fourth-generation cephalosporin antibiotics may help to combat the growing problem of resistant Pseudomonas aeruginosa.

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