Biosynthesis of Sulphur Amino Acids in Saccharomyces Cerevisiae: Regulatory Roles of Methionine and S-adenosylmethionine Reassessed

Overview

Journal Curr Genet

Specialty Genetics

Date 1992 Oct 1

PMID 1394507

Citations 6

Authors

A PASZEWSKI

B i Ono

Affiliations

Soon will be listed here.

Abstract

cys4-1, a mutation in the reverse trans-sulphuration pathway, relieves the sulphate assimilation pathway and homocysteine synthase from methionine-mediated repression. Since the mutation blocks the synthesis of cysteine from methionine downstream from homocysteine, this indicates that neither methionine nor S-adenosylmethionine serve as low-molecular-mass effectors in this regulatory system, contradicting earlier hypotheses.

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