Presynaptic Inhibition of the Spinal Monosynaptic Reflex Pathway

Overview

Journal J Physiol

Specialty Physiology

Date 1962 May 1

PMID 13889059

Citations 72

Authors

J C ECCLES

R F Schmidt

W D Willis

Affiliations

Soon will be listed here.

Citing Articles

Calretinin-expressing islet cells are a source of pre- and post-synaptic inhibition of non-peptidergic nociceptor input to the mouse spinal cord.

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Calretinin-expressing islet cells: a source of pre- and post-synaptic inhibition of non-peptidergic nociceptor input to the mouse spinal cord.

Davis O, Dickie A, Mustapa M, Boyle K, Browne T, Gradwell M bioRxiv. 2023; .

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Transcutaneous spinal stimulation in people with and without spinal cord injury: Effect of electrode placement and trains of stimulation on threshold intensity.

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Facilitation of sensory transmission to motoneurons during cortical or sensory-evoked primary afferent depolarization (PAD) in humans.

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Bumetanide increases postsynaptic inhibition after chronic SCI and decreases presynaptic inhibition with step-training.

Caron G, Bilchak J, Cote M J Physiol. 2023; 601(8):1425-1447.

PMID: 36847245 PMC: 10106440. DOI: 10.1113/JP283753.

References

ECCLES J, Eccles R, Magni F . Central inhibitory action attributable to presynaptic depolarization produced by muscle afferent volleys. J Physiol. 1961; 159:147-66. PMC: 1359583. DOI: 10.1113/jphysiol.1961.sp006798. View

ECCLES J, Kostyuk P, Schmidt R . Presynaptic inhibition of the central actions of flexor reflex afferents. J Physiol. 1962; 161:258-81. PMC: 1359622. DOI: 10.1113/jphysiol.1962.sp006885. View

Kuno M, Perl E . Alteration of spinal reflexes by interaction with suprasegmental and dorsal root activity. J Physiol. 1960; 151:103-22. PMC: 1363223. View

Bradley K, EASTON D, ECCLES J . An investigation of primary or direct inhibition. J Physiol. 1953; 122(3):474-88. PMC: 1366135. DOI: 10.1113/jphysiol.1953.sp005015. View

LONGO V . Spinal mechanisms involved in the convulsant action of 5,7-diphenyl-1,3-diazadamantan-6-ol (1757 I.S.). J Pharmacol Exp Ther. 1961; 132:240-4. View

Frank K, FUORTES M . Excitation and conduction. Annu Rev Physiol. 1961; 23:357-86. DOI: 10.1146/annurev.ph.23.030161.002041. View

ECCLES J . The mechanism of synaptic transmission. Ergeb Physiol. 1961; 51:299-430. View

ECCLES J, Eccles R, Lundberg A . Synaptic actions on motoneurones in relation to the two components of the group I muscle afferent volley. J Physiol. 1957; 136(3):527-46. PMC: 1358872. DOI: 10.1113/jphysiol.1957.sp005778. View

Cooper S, Creed R . More reflex effects of active muscular contraction. J Physiol. 1927; 64(3):199-214. PMC: 1514995. DOI: 10.1113/jphysiol.1927.sp002430. View

10.

ECCLES J, FATT P, Koketsu K . Cholinergic and inhibitory synapses in a pathway from motor-axon collaterals to motoneurones. J Physiol. 1954; 126(3):524-62. PMC: 1365877. DOI: 10.1113/jphysiol.1954.sp005226. View

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ECCLES J, Eccles R, Lundberg A . The convergence of monosynaptic excitatory afferents on to many different species of alpha motoneurones. J Physiol. 1957; 137(1):22-50. PMC: 1362996. DOI: 10.1113/jphysiol.1957.sp005794. View

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Araki T, EOCLES J, Ito M . Correlation of the inhibitory post-synaptic potential of motoneurones with the latency and time course of inhibition of monosynaptic reflexes. J Physiol. 1960; 154:354-77. PMC: 1359806. DOI: 10.1113/jphysiol.1960.sp006584. View

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ECCLES J, Eccles R, Lundberg A . Synaptic actions on motoneurones caused by impulses in Golgi tendon organ afferents. J Physiol. 1957; 138(2):227-52. PMC: 1363042. DOI: 10.1113/jphysiol.1957.sp005849. View

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HUNT C, Perl E . Spinal reflex mechanisms concerned with skeletal muscle. Physiol Rev. 1960; 40:538-79. DOI: 10.1152/physrev.1960.40.3.538. View

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Curtis D . Pharmacological investigations upon inhibition of spinal motoneurones. J Physiol. 1959; 145(1):175-92. PMC: 1356947. DOI: 10.1113/jphysiol.1959.sp006134. View

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FATT P . Biophysics of junctional transmission. Physiol Rev. 1954; 34(4):674-710. DOI: 10.1152/physrev.1954.34.4.674. View

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Bradley K, ECCLES J . Analysis of the fast afferent impulses from thigh muscles. J Physiol. 1953; 122(3):462-73. PMC: 1366134. DOI: 10.1113/jphysiol.1953.sp005014. View

18.

ECCLES J, Kostyuk P, Schmidt R . Central pathways responsible for depolarization of primary afferent fibres. J Physiol. 1962; 161:237-57. PMC: 1359621. DOI: 10.1113/jphysiol.1962.sp006884. View

19.

Eccles R, Lundberg A . Supraspinal control of interneurones mediating spinal reflexes. J Physiol. 1959; 147:565-84. PMC: 1357103. DOI: 10.1113/jphysiol.1959.sp006262. View

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ECCLES J, OSCARSSON O, Willis W . Synaptic action of group I and II afferent fibres of muscle on the cells of the dorsal spinocerebellar tract. J Physiol. 1961; 158:517-43. PMC: 1359981. DOI: 10.1113/jphysiol.1961.sp006783. View