The Origin and Function of Tumor-associated Macrophages

Overview

Journal Immunol Today

Specialty Allergy & Immunology

Date 1992 Jul 1

PMID 1388654

Citations 308

Authors

A Mantovani

B Bottazzi

F Colotta

S Sozzani

L Ruco

Affiliations

Soon will be listed here.

Abstract

Tumor-associated macrophages (TAM) have a complex relationship with the neoplastic cells of the tumor. On the one hand, the two cell types produce reciprocal growth factors and may be considered to have a symbiotic relationship. On the other hand, TAM can be activated to inhibit tumor growth and destroy neoplastic cells. Here, Alberto Mantovani and colleagues describe this delicate balance and the prospects for its therapeutic manipulation.

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