D1-dopamine Receptors Activate C-fos Expression in the Fetal Suprachiasmatic Nuclei

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1992 Oct 1

PMID 1384044

Citations 23

Authors

D R Weaver

S A Rivkees

S M Reppert

Affiliations

Soon will be listed here.

Abstract

The existence of an activatable dopamine system within the hypothalamic suprachiasmatic nuclei (SCN), the site of a biological clock, was investigated in rats during fetal life. In situ hybridization studies revealed that D1-dopamine receptor mRNA was highly expressed in the fetal SCN and not expressed in other hypothalamic regions. Cocaine injected into pregnant rats or directly into rat fetuses on day 20 of gestation selectively activated c-fos gene expression in the fetal SCN; cocaine did not induce c-fos expression elsewhere in the fetal brain or in the maternal SCN. This cocaine-induced activation of c-fos expression in fetal SCN was mediated in part through D1-dopamine receptors, as the cocaine-induced activation was partially blocked by the D1-dopamine receptor antagonist SCH 23390. In addition, the selective D1-dopamine receptor agonist SKF 38393 induced high levels of c-fos expression in the fetal SCN. The presence of an activatable dopamine system within the fetal SCN provides a mechanism through which maternal signals could entrain the fetal biological clock and through which maternally administered psychotropic drugs could alter normal development of the circadian timing system.

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References

Reppert S, Weaver D, Rivkees S, Stopa E . Putative melatonin receptors in a human biological clock. Science. 1988; 242(4875):78-81. DOI: 10.1126/science.2845576. View

Zuckerman B, Frank D, Hingson R, Amaro H, LEVENSON S, KAYNE H . Effects of maternal marijuana and cocaine use on fetal growth. N Engl J Med. 1989; 320(12):762-8. DOI: 10.1056/NEJM198903233201203. View

Young S, Porrino L, Iadarola M . Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors. Proc Natl Acad Sci U S A. 1991; 88(4):1291-5. PMC: 51003. DOI: 10.1073/pnas.88.4.1291. View

Morgan J, Curran T . Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Annu Rev Neurosci. 1991; 14:421-51. DOI: 10.1146/annurev.ne.14.030191.002225. View

Laemle L, Repke K, Hawkes R, Rice F . Synaptogenesis in the rat suprachiasmatic nucleus: a light microscopic immunocytochemical survey. Brain Res. 1991; 544(1):108-17. DOI: 10.1016/0006-8993(91)90891-x. View

Fremeau Jr R, Duncan G, Fornaretto M, Dearry A, Gingrich J, Breese G . Localization of D1 dopamine receptor mRNA in brain supports a role in cognitive, affective, and neuroendocrine aspects of dopaminergic neurotransmission. Proc Natl Acad Sci U S A. 1991; 88(9):3772-6. PMC: 51535. DOI: 10.1073/pnas.88.9.3772. View

Aronin N, Sagar S, Sharp F, Schwartz W . Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei. Proc Natl Acad Sci U S A. 1990; 87(15):5959-62. PMC: 54449. DOI: 10.1073/pnas.87.15.5959. View

Graybiel A, Moratalla R, Robertson H . Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum. Proc Natl Acad Sci U S A. 1990; 87(17):6912-6. PMC: 54648. DOI: 10.1073/pnas.87.17.6912. View

van den Pol A, Tsujimoto K . Neurotransmitters of the hypothalamic suprachiasmatic nucleus: immunocytochemical analysis of 25 neuronal antigens. Neuroscience. 1985; 15(4):1049-86. DOI: 10.1016/0306-4522(85)90254-4. View

10.

Rea M . Light increases Fos-related protein immunoreactivity in the rat suprachiasmatic nuclei. Brain Res Bull. 1989; 23(6):577-81. DOI: 10.1016/0361-9230(89)90204-9. View

11.

Ugrumov M, Tixier-Vidal A, Taxi J, Thibault J, MITSKEVICH M . Ontogenesis of tyrosine hydroxylase-immunopositive structures in the rat hypothalamus. Fiber pathways and terminal fields. Neuroscience. 1989; 29(1):157-66. DOI: 10.1016/0306-4522(89)90339-4. View

12.

Meijer J, Rietveld W . Neurophysiology of the suprachiasmatic circadian pacemaker in rodents. Physiol Rev. 1989; 69(3):671-707. DOI: 10.1152/physrev.1989.69.3.671. View

13.

Dubocovich M . Pharmacology and function of melatonin receptors. FASEB J. 1988; 2(12):2765-73. DOI: 10.1096/fasebj.2.12.2842214. View

14.

Moore R, Card J . Visual pathways and the entrainment of circadian rhythms. Ann N Y Acad Sci. 1985; 453:123-33. DOI: 10.1111/j.1749-6632.1985.tb11805.x. View

15.

Frank D, Zuckerman B, Amaro H, Aboagye K, Bauchner H, Cabral H . Cocaine use during pregnancy: prevalence and correlates. Pediatrics. 1988; 82(6):888-95. View

16.

Garabal M, Arevalo R, Castro R, Rodriguez M . Tyrosine availability and brain noradrenaline synthesis in the fetus: control by maternal tyrosine ingestion. Brain Res. 1988; 457(2):330-7. DOI: 10.1016/0006-8993(88)90703-2. View

17.

Davis F, Mannion J . Entrainment of hamster pup circadian rhythms by prenatal melatonin injections to the mother. Am J Physiol. 1988; 255(3 Pt 2):R439-48. DOI: 10.1152/ajpregu.1988.255.3.R439. View

18.

Reppert S, Schwartz W . Maternal coordination of the fetal biological clock in utero. Science. 1983; 220(4600):969-71. DOI: 10.1126/science.6844923. View

19.

Zisapel N, Laudon M . Dopamine release induced by electrical field stimulation of rat hypothalamus in vitro: inhibition by melatonin. Biochem Biophys Res Commun. 1982; 104(4):1610-6. DOI: 10.1016/0006-291x(82)91437-1. View

20.

Chasnoff I, GRIFFITH D, MacGregor S, Dirkes K, Burns K . Temporal patterns of cocaine use in pregnancy. Perinatal outcome. JAMA. 1989; 261(12):1741-4. View