Are Stretch-sensitive Channels in Molluscan Cells and Elsewhere Physiological Mechanotransducers?

Overview

Journal Experientia

Specialty Science

Date 1992 Sep 15

PMID 1383023

Citations 7

Authors

C E Morris

Affiliations

Soon will be listed here.

Abstract

Single-channel recordings of dozens of cell types, including invertebrate (molluscan) and vertebrate heart cells, reveal stretch-sensitive ion channels. The physiological roles of these channels are undoubtedly diverse but it is usually assumed that the roles they play are related to the channels' mechanosensitive gating. Whether this assumption is valid remains to be seen. Attempts to connect the single-channel observations with the mechanical aspects of physiological or developmental processes are discussed. In the case of molluscan cells, recent work suggests that their stretch channels have physiological functions unrelated to mechanosensitive gating.

Citing Articles

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Stretch-activation and stretch-inactivation of Shaker-IR, a voltage-gated K+ channel.

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Regulation of the epithelial Na+ channel by membrane tension.

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Pharmacology of stretch-activated K channels in Lymnaea neurones.

Small D, Morris C Br J Pharmacol. 1995; 114(1):180-6.

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