Nitric Oxide: a Physiologic Mediator of Penile Erection

Overview

Journal Science

Specialty Science

Date 1992 Jul 17

PMID 1378650

Citations 204

Authors

A L Burnett

C J Lowenstein

D S Bredt

T S Chang

S H Snyder

Affiliations

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Abstract

Nitric oxide (NO) is a cytotoxic agent of macrophages, a messenger molecule of neurons, and a vasodilator produced by endothelial cells. NO synthase, the synthetic enzyme for NO, was localized to rat penile neurons innervating the corpora cavernosa and to neuronal plexuses in the adventitial layer of penile arteries. Small doses of NO synthase inhibitors abolished electrophysiologically induced penile erections. These results establish NO as a physiologic mediator of erectile function.

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