Rapid Development of Drug-resistant Mutants of Poliovirus

Overview

Journal Science

Specialty Science

Date 1961 Aug 25

PMID 13769274

Citations 19

Authors

J L Melnick

D Crowther

J BARRERA-ORO

Affiliations

Soon will be listed here.

Abstract

Guanidine hydrochloride is a potent inhibitor of poliovirus synthesis in cell culture. However, the viral progeny which do grow in the presence of guani-dine may become approximately 10,000 times more resistant to the drug. The phenomenon of drug resistance poses yet another problem in the search for a satisfactory viral chemotherapeutic agent.

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