The Physiological Role of the Ketone Bodies

Overview

Journal Biochem J

Specialty Biochemistry

Date 1961 Aug 1

PMID 13754174

Citations 25

Authors

H A KREBS

Affiliations

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Citing Articles

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Fasting mitigates immediate hypersensitivity: a pivotal role of endogenous D-beta-hydroxybutyrate.

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References

Hayward A, Forsyth W, ROBERTS J . Synthesis and breakdown of poly-beta-hydroxybutyric acid by bacteria. J Gen Microbiol. 1959; 20(3):510-8. DOI: 10.1099/00221287-20-3-510. View

Devlin T, BEDELL B . Effect of acetoacetate on the oxidation of reduced diphosphopyridine nucleotide by intact rat liver mitochondria. J Biol Chem. 1960; 235:2134-9. View

Klingenberg M, Schollmeyer P . [On the reversibility of oxidative phosphorylation. Adenosine triphosphate-dependent respiratory control and reduction of diphosphopyridine nucleotide in mitochondria]. Biochem Z. 1960; 333:335-50. View

Lynen F, Ochoa S . Enzymes of fatty acid metabolism. Biochim Biophys Acta. 1953; 12(1-2):299-314. DOI: 10.1016/0006-3002(53)90149-8. View

Stephenson M . Obituary Notice: Frederick Gowland Hopkins, 1861-1947. Biochem J. 1948; 42(2):161.b2-169. PMC: 1258648. View

Jowett M, QUASTEL J . Studies in fat metabolism: The formation and breakdown of acetoacetic acid in animal tissues. Biochem J. 1935; 29(9):2181-91. PMC: 1266740. DOI: 10.1042/bj0292181. View

Kimura T, SINGER T, LUSTY C . Studies on choline dehydrogenase. III. Organization of the respiratory chain in choline oxidase. Biochim Biophys Acta. 1960; 44:284-97. DOI: 10.1016/0006-3002(60)91564-x. View

Odum E, CONNELL C . Lipid levels in migrating birds. Science. 1956; 123(3203):892-4. DOI: 10.1126/science.123.3203.892-a. View

Klingenberg M, Slenczka W, RITT E . [Comparative biochemistry of the pyridine nucleotide system in the mitochondria of various organs]. Biochem Z. 1959; 332:47-66. View

10.

KREBS H, EGGLESTON L, DAlessandro A . The effect of succinate and amytal on the reduction of acetoacetate in animal tissues. Biochem J. 1961; 79:537-49. PMC: 1205683. DOI: 10.1042/bj0790537. View

11.

Peters R . The faith of a master in biochemistry; the first Hopkins Memorial Lecture. Biochem J. 1959; 71(1):1-9. PMC: 1196739. DOI: 10.1042/bj0710001. View

12.

Birt L, Bartley W . The pyridine nucleotide metabolism of mitochondria incubated with and without added substrates and metabolic inhibitors. Biochem J. 1960; 76(3):427-38. PMC: 1204816. DOI: 10.1042/bj0760427. View

13.

Campbell J, BEST C . Physiologic aspects of ketosis. Metabolism. 1956; 5(2):95-113. View

14.

KULKA R, KREBS H, EGGLESTON L . The reduction of acetoacetate to beta-hydroxybutyrate in animal tissues. Biochem J. 1961; 78:95-106. PMC: 1205179. DOI: 10.1042/bj0780095. View

15.

Chance B . Energy-linked cytochrome oxidation in mitochondria. Nature. 1961; 189:719-25. DOI: 10.1038/189719b0. View

16.

Bleehen N, FISHER R . The action of insulin in the isolated rat heart. J Physiol. 1954; 123(2):260-76. PMC: 1366200. DOI: 10.1113/jphysiol.1954.sp005049. View

17.

BALLARD F, Danforth W, NAEGLE S, BING R . Myocardial metabolism of fatty acids. J Clin Invest. 1960; 39:717-23. PMC: 293363. DOI: 10.1172/JCI104088. View

18.

Pugh L, Edholm O, Fox R, Wolff H, Hervey G, HAMMOND W . A physiological study of channel swimming. Clin Sci. 1960; 19:257-73. View

19.

WERTHEIMER E, BEN-TOR V . Fat utilization by muscle. Biochem J. 1952; 50(4):573-6. PMC: 1197704. DOI: 10.1042/bj0500573. View

20.

Lehninger A, GREVILLE G . The enzymic oxidation of alpha- and 2-beta-hydroxybutyrate. Biochim Biophys Acta. 1953; 12(1-2):188-202. DOI: 10.1016/0006-3002(53)90138-3. View