Caudate Nucleus Pathology in Parkinson's Disease: Ultrastructural and Biochemical Findings in Biopsy Material

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1992 Jan 1

PMID 1374203

Citations 18

Authors

B Lach

D Grimes

B Benoit

Affiliations

Soon will be listed here.

Abstract

Ultrastructural and biochemical properties of caudate nucleus (CN) biopsies in two patients with advanced Parkinson's disease (PD) were compared with three CN specimens removed during surgery for intracranial tumors. An additional two specimens from neurologically intact patients (59 and 86 years old) were removed during autopsy (performed 3 and 4 h post mortem, respectively) for electron microscopic studies. Dopamine levels in PD were reduced to less than 15% of control values. Both PD patients showed frequent dystrophic neurites and transsynaptic degeneration of neurons and neuritic processes. These changes were not found in CN from the four control individuals. Only a few dystrophic neurites were noticed in one 67-year-old control patient. The development of neuroaxonal dystrophy in CN is consistent with a dying-back process, probably accompanying abnormalities of axonal transport in PD. Transsynaptic degeneration of neurons in CN very likely represents a morphological marker of disease severity. The occurrence of this change may account for the poor clinical response of patients with advanced PD to intracerebral implantation of dopaminergic tissues.

Citing Articles

Dopaminergic denervation and associated MRI microstructural changes in the nigrostriatal projection in early Parkinson's disease patients.

Lopez-Aguirre M, Matarazzo M, Blesa J, Monje M, Rodriguez-Rojas R, Sanchez-Ferro A NPJ Parkinsons Dis. 2023; 9(1):144.

PMID: 37852988 PMC: 10584921. DOI: 10.1038/s41531-023-00586-x.

Clinical Trial Highlights: Modulators of Mitochondrial Function.

Capriglia F, Burgess T, Bandmann O, Mortiboys H J Parkinsons Dis. 2023; 13(6):851-864.

PMID: 37694310 PMC: 10578225. DOI: 10.3233/JPD-239003.

The Role of Bacteria-Mitochondria Communication in the Activation of Neuronal Innate Immunity: Implications to Parkinson's Disease.

Magalhaes J, Esteves A, Candeias E, Silva D, Empadinhas N, Cardoso S Int J Mol Sci. 2023; 24(5).

PMID: 36901773 PMC: 10001700. DOI: 10.3390/ijms24054339.

Dopamine D3 Receptor in Parkinson Disease: A Prognosis Biomarker and an Intervention Target.

Xu J Curr Top Behav Neurosci. 2022; 60:89-107.

PMID: 35711029 PMC: 10034716. DOI: 10.1007/7854_2022_373.

Mitochondrial Supercomplexes: Physiological Organization and Dysregulation in Age-Related Neurodegenerative Disorders.

Novack G, Galeano P, Castano E, Morelli L Front Endocrinol (Lausanne). 2020; 11:600.

PMID: 33042002 PMC: 7518391. DOI: 10.3389/fendo.2020.00600.

References

Bouyer J, Park D, Joh T, Pickel V . Chemical and structural analysis of the relation between cortical inputs and tyrosine hydroxylase-containing terminals in rat neostriatum. Brain Res. 1984; 302(2):267-75. DOI: 10.1016/0006-8993(84)90239-7. View

Freund T, Powell J, Smith A . Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines. Neuroscience. 1984; 13(4):1189-215. DOI: 10.1016/0306-4522(84)90294-x. View

Allen R, Weiss D, Hayden J, Brown D, Fujiwake H, Simpson M . Gliding movement of and bidirectional transport along single native microtubules from squid axoplasm: evidence for an active role of microtubules in cytoplasmic transport. J Cell Biol. 1985; 100(5):1736-52. PMC: 2113850. DOI: 10.1083/jcb.100.5.1736. View

Jones W, Thomas D . Changes in the dendritic organization of neurons in the cerebral cortex following deafferentation. J Anat. 1962; 96:375-81. PMC: 1244121. View

Mann D, YATES P . Pathological basis for neurotransmitter changes in Parkinson's disease. Neuropathol Appl Neurobiol. 1983; 9(1):3-19. DOI: 10.1111/j.1365-2990.1983.tb00320.x. View

Wilson C, Groves P . Fine structure and synaptic connections of the common spiny neuron of the rat neostriatum: a study employing intracellular inject of horseradish peroxidase. J Comp Neurol. 1980; 194(3):599-615. DOI: 10.1002/cne.901940308. View

Zalcman S, Shanks N, Anisman H . Time-dependent variations of central norepinephrine and dopamine following antigen administration. Brain Res. 1991; 557(1-2):69-76. DOI: 10.1016/0006-8993(91)90117-e. View

De Coster W, Roels H, VANDER EECKEN H . Electron microscopical study of neuroaxonal dystrophy. Case report. Eur Neurol. 1971; 5(2):65-83. DOI: 10.1159/000114061. View

FORNO L . The Lewy body in Parkinson's disease. Adv Neurol. 1987; 45:35-43. View

10.

Dickson D, Wertkin A, Kress Y, Ksiezak-Reding H, Yen S . Ubiquitin immunoreactive structures in normal human brains. Distribution and developmental aspects. Lab Invest. 1990; 63(1):87-99. View

11.

Pappolla M . Lewy bodies of Parkinson's disease. Immune electron microscopic demonstration of neurofilament antigens in constituent filaments. Arch Pathol Lab Med. 1986; 110(12):1160-3. View

12.

Hedley-Whyte E, Gilles F, Uzman B . Infantile neuroaxonal dystrophy. A disease characterized by altered terminal axons and synaptic endings. Neurology. 1968; 18(9):891-906. DOI: 10.1212/wnl.18.9.891. View

13.

Sotelo C, PALAY S . Altered axons and axon terminals in the lateral vestibular nucleus of the rat. Possible example of axonal remodeling. Lab Invest. 1971; 25(6):653-71. View

14.

LAMPERT P . A comparative electron microscopic study of reactive, degenerating, regenerating, and dystrophic axons. J Neuropathol Exp Neurol. 1967; 26(3):345-68. DOI: 10.1097/00005072-196707000-00001. View

15.

Goldstein M, Lieberman A, Helmer E, Koslow M, Ransohoff J, Elsworth J . Biochemical analysis of caudate nucleus biopsy samples from parkinsonian patients. Ann Neurol. 1988; 24(5):685-8. DOI: 10.1002/ana.410240517. View

16.

Kish S, Rajput A, Gilbert J, ROZDILSKY B, Chang L, Shannak K . Elevated gamma-aminobutyric acid level in striatal but not extrastriatal brain regions in Parkinson's disease: correlation with striatal dopamine loss. Ann Neurol. 1986; 20(1):26-31. DOI: 10.1002/ana.410200106. View

17.

Scherman D, Desnos C, Darchen F, Pollak P, Agid Y . Striatal dopamine deficiency in Parkinson's disease: role of aging. Ann Neurol. 1989; 26(4):551-7. DOI: 10.1002/ana.410260409. View

18.

Hornykiewicz O, Kish S . Biochemical pathophysiology of Parkinson's disease. Adv Neurol. 1987; 45:19-34. View

19.

Kish S, Shannak K, Hornykiewicz O . Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications. N Engl J Med. 1988; 318(14):876-80. DOI: 10.1056/NEJM198804073181402. View

20.

Pickel V, Beckley S, Joh T, Reis D . Ultrastructural immunocytochemical localization of tyrosine hydroxylase in the neostriatum. Brain Res. 1981; 225(2):373-85. DOI: 10.1016/0006-8993(81)90843-x. View