Cross-neutralization Studies with Group A Arthropod-borne Viruses

Overview

Journal Bull World Health Organ

Specialty Public Health

Date 1961 Jan 1

PMID 13737288

Citations 10

Authors

J S PORTERFIELD

Affiliations

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Abstract

In an extension of recent work on the antigenic interrelationships of arthropod-borne viruses, the plaque-inhibition test has been applied to the study of 15 Group A strains. Middelburg and eastern equine encephalomyelitis viruses show no relationship to any other virus in the group. Sindbis and western equine encephalomyelitis viruses show a one-way relationship only. The remaining viruses all share some antigenic components which react with hyperimmune rabbit sera prepared against Semliki Forest virus. However, using single-dose rabbit sera, or more specific mouse-immune sera, four distinct subgroups can be defined. One includes Semliki Forest virus strains; another Chikungunya virus and its substrains, Vereeniging and TH 35 viruses; the third contains O'nyong-nyong virus; and the fourth Mayaro and Uruma viruses.This paper also demonstrates how the plaque-inhibition technique may be used for the rapid identification of new virus isolates.

Citing Articles

Neutralizing Antibodies from Convalescent Chikungunya Virus Patients Can Cross-Neutralize Mayaro and Una Viruses.

Martins K, Gregory M, Valdez S, Sprague T, Encinales L, Pacheco N Am J Trop Med Hyg. 2019; 100(6):1541-1544.

PMID: 31017081 PMC: 6553899. DOI: 10.4269/ajtmh.18-0756.

Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress.

Fox J, Long F, Edeling M, Lin H, van Duijl-Richter M, Fong R Cell. 2015; 163(5):1095-1107.

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Identifying the Role of E2 Domains on Alphavirus Neutralization and Protective Immune Responses.

Weger-Lucarelli J, Aliota M, Kamlangdee A, Osorio J PLoS Negl Trop Dis. 2015; 9(10):e0004163.

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Neutralising antibodies for Mayaro virus in Pantanal, Brazil.

Pauvolid-Correa A, Juliano R, Campos Z, Velez J, Nogueira R, Komar N Mem Inst Oswaldo Cruz. 2015; 110(1):125-33.

PMID: 25742272 PMC: 4371226. DOI: 10.1590/0074-02760140383.

High rates of o'nyong nyong and Chikungunya virus transmission in coastal Kenya.

LaBeaud A, Banda T, Brichard J, Muchiri E, Mungai P, Mutuku F PLoS Negl Trop Dis. 2015; 9(2):e0003436.

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