Effects of 3-methylcholanthrene and Phenobarbital on Amino Acid Incorporation into Protein

Overview

Journal Science

Specialty Science

Date 1961 Sep 1

PMID 13704253

Citations 12

Authors

H V Gelboin

L Sokoloff

Affiliations

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Abstract

Treatment of rats with methylcholanthrene and phenobarbital, two compounds known to enhance microsomal enzyme activity, stimulates the incorporation of free or soluble ribonucleic acid bound amino acid into proteins of cell-free liver preparations. Mitochondria, microsomes, and cell sap all contribute to the methylcholanthrene effect on the incorporation of free amino acid.

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Studies on azo-dye carcinogenesis in rat liver. The effect of 4-dimethylamino-3'-methylazobenzene on the incorporation of [C]leucine into rat-liver microsomal protein.

Hawtrey A, Schirren V, Dijkstra J Biochem J. 1963; 88(1):106-14.

PMID: 16749021 PMC: 1203857. DOI: 10.1042/bj0880106.

METHYLCHOLANTHRENE-INDUCED CHANGES IN RAT LIVER NUCLEAR RNA.

Loeb L, Gelboin H Proc Natl Acad Sci U S A. 1964; 52:1219-26.

PMID: 14231444 PMC: 300426. DOI: 10.1073/pnas.52.5.1219.

[Enzyme induction and increase of endoplasmic reticulum in liver cells during phenobarbital (Luminal) therapy].

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Macdonald W, Macqueen J, DEICHMANN W, Hamill T, Copsey K Int Arch Arbeitsmed. 1970; 26(1):31-44.

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Phenobarbital-induced synthesis of the microsomal drug-metabolizing enzyme system and its relationship to the proliferation of endoplasmic membranes. A morphological and biochemical study.

Orrenius S, Ericsson J, Ernster L J Cell Biol. 1965; 25(3):627-39.

PMID: 4378769 PMC: 2106691. DOI: 10.1083/jcb.25.3.627.