Effect of Different Sex of Tumour Bearing Mice and of Ovariectomy on the Proliferation Kinetics of a Solid, Transplantable Mammary Carcinoma (C3H-mouse)

Overview

Journal Z Krebsforsch Klin Onkol Cancer Res Clin Oncol

Specialty Oncology

Date 1976 Jan 1

PMID 136825

Citations 2

Authors

W Feaux de Lacroix

F J Hensen

P J Klein

E Nola

K J LENNARTZ

Affiliations

Soon will be listed here.

Abstract

The aim of the present investigation was to study the influence of sex of tumour bearing mice and of ovariectomy on the proliferation kinetics of a solid, transplantable mammary carcinoma (C3H-mouse). According to the growth curves the tumour growth was delayed in spayed female and in male mice compared with normal female animals. This was due to a longer cell cycle time of tumour cells in the former, mainly caused by a prolonged presynthetic gap (TG1). Concerning the growth fraction and the cell loss factor, essential differences could not be detected. Thus, the solid tumour displayed a distinct though partial disengagement of growth from hormonal dependence.

Citing Articles

Comparative investigations on the effect of the phase-specific drug vincristine (VCR) on the proliferation kinetics of a solid experimental tumor.

Feaux de Lacroix W, Klein M J Cancer Res Clin Oncol. 1983; 106(3):187-91.

PMID: 6654953 DOI: 10.1007/BF00402606.

Age-dependent change of the effect of a cytostatic drug on the proliferation kinetics of a solid tumor of the mouse.

Feaux de Lacroix W, Weyer M, Schutt A, LENNARTZ K J Cancer Res Clin Oncol. 1979; 94(1):29-37.

PMID: 468897 DOI: 10.1007/BF00405347.

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