Metal-binding Sites in Proteins

Overview

Journal Curr Opin Biotechnol

Publisher Elsevier

Specialty Biotechnology

Date 1991 Aug 1

PMID 1367679

Citations 39

Authors

J A Tainer

V A Roberts

E D Getzoff

Affiliations

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Abstract

A dramatic increase in the number of solved metalloprotein structures and recent breakthroughs in structural analysis have provided a sufficiently detailed understanding of the structural chemistry of some metal-binding sites to allow successful design. As a result, metal-binding site design is now one of the most powerful and promising approaches for influencing protein folding, assembly, stability and catalysis.

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